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HCN channels reveal conserved and divergent physiology in supragranular pyramidal neurons in primate species
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ID: paper-40894563
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HCN channels reveal conserved and divergent physiology in supragranular pyramidal neurons in primate species
["Radaelli C", "Schmitz M", "Liu X", "Sawchuk S", "Opitz-Araya X", "Hudson M", "Taskin N", "Bertagnolli D", "Goldy J", "Ko A"]
Abstract
The physiological properties of human and rodent neurons differ, yet the extent to which these differences reflect human specializations is often unclear. Compared with their rodent counterparts, human supragranular pyramidal neurons possess enriched HCN-channel-dependent intrinsic membrane properties and a related sensitivity to synaptic inputs containing delta/theta band frequencies. We tested whether other primate species possess enriched HCN-channel dependent membrane properties. We found ub...
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