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The MAP6-NTS axis in hippocampal CA1 regulates synaptic plasticity and memory.
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ID: paper-41825505
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The MAP6-NTS axis in hippocampal CA1 regulates synaptic plasticity and memory.
Jia Y, Lei J, Jiang Y, Xue L, Chen T, Wang J, Wei H
Abstract
Microtubule-associated Protein 6 (MAP6) is critical for maintaining microtubule stability and synaptic plasticity, and its dysfunction is a key driver of cognitive impairment. However, the molecular mechanisms linking MAP6 deletion to cognitive deficits remain unclear. Here, we generated a novel Map6 knockout (KO, Map6-/-) mouse model using CRISPR/Cas9-mediated genome editing. Behavioral tests confirmed that Map6-/- mice exhibited prominent cognitive impairments, primarily in long-term memory an...
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