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STING Degradation by PRRSV Activates HK2-Mediated Glycolysis to Facilitate Viral Replication.
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ID: paper-41902192
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STING Degradation by PRRSV Activates HK2-Mediated Glycolysis to Facilitate Viral Replication.
Luo L, Zhou L, Gao X, Li Y, Zhou H, Li Y, Zhang Z
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) infection relies on glycolytic reprogramming to support replication, but the mechanisms driving this metabolic shift remain poorly understood. The stimulator of interferon genes (STING), an innate immune adaptor, recently emerged as a metabolic regulator by directly binding and inhibiting hexokinase-2 (HK2), a key rate-limiting enzyme in glycolysis. Whether PRRSV exploits the STING-HK2 axis to unleash glycolysis for its own replication ...
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