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Mir147 Limits the Contribution of Non-Foamy Macrophages to Atherosclerosis.
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ID: paper-41944070
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Mir147 Limits the Contribution of Non-Foamy Macrophages to Atherosclerosis.
Li N, Taherdangkoo K, Baatsch IM, Guduru T, Meng Q et al.
Abstract
BACKGROUND: Hypercholesterolemia and a high-fat diet promote 2 macrophage subtypes involved in atherosclerosis by inducing lipid droplet accumulation in foamy macrophages (FMs) and inflammatory activation in non-foamy macrophages (NFMs). MicroRNAs are key regulators of macrophage function; for instance, METHODS: The role of RESULTS: Unlike FMs, NFMs are primarily located in the plaque core and show higher CONCLUSIONS:
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