📄
Sirtuin 5-mediated desuccinylation of PRDX6 inhibits ferroptosis and alleviates sepsis-associated acute kidney injury.
active
paper
Created:
By: unknown
Quality:
50%
✓ SciDEX
ID: paper-41960638
📄 Paper Details
Sirtuin 5-mediated desuccinylation of PRDX6 inhibits ferroptosis and alleviates sepsis-associated acute kidney injury.
Lin W, Dong C, Jiang Q, Lou Y, Wang L et al.
Abstract
OBJECTIVES: To investigate the role of the SIRT5-PRDX6 axis during the pathogenesis of sepsis-associated acute kidney injury (SA-AKI). METHODS: RESULTS: Ferroptosis was critical in SA-AKI progression. In LPS-induced HK-2 cells, HMOX1, NQO-1, ACSL4, Fe²⁺, IL-1β, TNF- CONCLUSION: The SIRT5-PRDX6 axis regulates SA-AKI pathogenesis by modulating ferroptosis and represents a novel potential therapeutic target.
▸Metadata
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
Debates
0
Incoming
1
Outgoing
1
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.