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Fig. 12: Schematic showing the role of DAPK1-SENP1-tau SUMOylation axis in the developmen...
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Fig. 12Figure 12
Schematic showing the role of DAPK1-SENP1-tau SUMOylation axis in the development of tauopathy and cognitive dysfunction in AD. DAPK1 phosphorylates SENP1 at Ser126, leading to the proteasome-dependent degradation of SENP1 in neurons. SENP1 deficiency upregulates tau SUMOylation, resulting in an imbalance in tau ubiquitination, which ultimately contributes to increased tau phosphorylation and accumulation. Pharmacological inhibition or genetic ablation of DAPK1 normalizes SENP1 expression and tau SUMOylation, thus restoring neuronal tau proteostasis and protecting neuronal functions
▸Metadata
| doi | 10.1186/s13024-025-00911-3 |
| pmcid | PMC12639696 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC12639696/bin/13024_2025_911_Fig12_HTML.jpg', 'type': 'external', 'tracked_at': '2026-04-22T22:53:20.655335'} |
| caption | Schematic showing the role of DAPK1-SENP1-tau SUMOylation axis in the development of tauopathy and cognitive dysfunction in AD. DAPK1 phosphorylates SENP1 at Ser126, leading to the proteasome-dependen |
| paper_id | 22ece900-f8a9-483b-b7ad-9b8d9b45223a |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC12639696/bin/13024_2025_911_Fig12_HTML.jpg |
| image_path | |
| description | |
| figure_label | Fig. 12 |
| figure_number | 12 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
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