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FIGURE 1: Associations of epigenetic clocks with plasma biomarkers of ADRD at baseline. As...
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Created: 2026-04-25T22:26:46
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ID: paper-fig-41399190-1
FIGURE 1Figure 1
Associations of epigenetic clocks with plasma biomarkers of ADRD at baseline. Associations between epigenetic clocks and plasma biomarkers were based on linear regression models. Standardized log 2 ‐transformed biomarker levels are shown with 95% confidence intervals per 1‐SD increase in epigenetic clocks. Epigenetic clocks include AgeAccelHorvath (SD 5.38), AgeAccelHannum (SD 5.01), AgeAccelPheno (SD 6.80), AgeAccelGrim2 (SD 4.37), DunedinPACE (SD 0.11), PCPhenoAge (SD 6.47), and PCGrimAge (SD 3.20). Biomarkers include Aβ42:Aβ40, p‐tau181, p‐tau217, NfL, and GFAP. Standard deviation of log 2 ‐transformed biomarker values used in model fitting: Aβ42:Aβ40 (SD 0.31), p‐tau181 (SD 0.55), p‐tau217 (SD 0.81), NfL (SD 0.59), and GFAP (SD 0.63). Models were adjusted for chronological age, hormone therapy treatment arm, education, smoking status, race, ethnicity, physical activity, body mass index, diabetes, cardiovascular disease, hypertension, total cholesterol, HDL cholesterol, estimated gl
▸Metadata
| doi | |
| pmcid | PMC12706121 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC12706121/bin/ALZ-21-e70983-g003.jpg', 'type': 'external', 'tracked_at': '2026-04-26T05:26:46.486681'} |
| caption | Associations of epigenetic clocks with plasma biomarkers of ADRD at baseline. Associations between epigenetic clocks and plasma biomarkers were based on linear regression models. Standardized log 2 ‐t |
| paper_id | 41399190 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC12706121/bin/ALZ-21-e70983-g003.jpg |
| image_path | |
| description | |
| figure_label | FIGURE 1 |
| figure_number | 1 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
📊 Evidence Profile
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