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FIGURE 4: Estimated changes in plasma biomarkers of ADRD over an average of 15 years acros...
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FIGURE 4Figure 4
Estimated changes in plasma biomarkers of ADRD over an average of 15 years across 3 levels of DunedinPACE from a fully adjusted linear mixed‐effects model. Linear mixed‐effects models contained random intercepts and slopes adjusted for chronological age, time since baseline in decades, hormone therapy treatment arm, education, smoking status, race, ethnicity, physical activity, body mass index, diabetes, cardiovascular disease, hypertension, total cholesterol, HDL cholesterol, estimated glomerular filtration rate, and white blood cell counts (CD8T, CD4T, natural killer cells, B cells, monocytes, and neutrophils). An interaction term between DunedinPACE and time was included. Results are Z‐transformed DunedinPACE set to the mean (1.05), 1 SD below (0.94) and above the mean (1.16) at baseline. Biomarkers include GFAP, NfL, p‐tau181, and p‐tau217. ADRD, Alzheimer's disease and related dementias; GFAP, glial fibrillary acidic protein; NfL, neurofilament light; p‐tau181, tau phosphorylated
▸Metadata
| doi | |
| pmcid | PMC12706121 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC12706121/bin/ALZ-21-e70983-g004.jpg', 'type': 'external', 'tracked_at': '2026-04-26T05:26:46.960863'} |
| caption | Estimated changes in plasma biomarkers of ADRD over an average of 15 years across 3 levels of DunedinPACE from a fully adjusted linear mixed‐effects model. Linear mixed‐effects models contained random |
| paper_id | 41399190 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC12706121/bin/ALZ-21-e70983-g004.jpg |
| image_path | |
| description | |
| figure_label | FIGURE 4 |
| figure_number | 4 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
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