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Fig. 3: CREB1 controls the unfolded protein response in MM. A Schema of the UPR signali...
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Created: 2026-04-27T05:03:36
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Fig. 3Figure 3
CREB1 controls the unfolded protein response in MM. A Schema of the UPR signaling pathway. The UPR activates pro-apoptotic pathways when ER stress is prolonged, leading to the activation of BAX, BAK, and caspases 12 and 3, which promote apoptosis. CHOP, induced by ATF4, also promotes apoptosis by inhibiting BCL2 and triggering mitochondrial dysfunction via BID. Concurrently, to cope with ER stress, the UPR also initiates adaptive responses through the PERK, ATF6, and IRE1 pathways, leading to a general reduction in protein translation and enhanced expression of genes involved in protein folding and ER-associated degradation. B PERK, EI2FA, IRE1, XBP1, and ATF6 log 2 expression values based on median CREB1 expression in the MMRF CoMMpass database. Black dashed lines represent the median value, black dotted lines represent the 25 th and 75 th percentiles, n = 770 patients. PERK p < 0.0001, ****; ATF6 p = 0.0002, ***. All other comparisons are not significant, ns, Student’s t
▸Metadata
| doi | 10.1038/s41419-025-08246-z |
| pmcid | PMC12811356 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC12811356/bin/41419_2025_8246_Fig3_HTML.jpg', 'type': 'external', 'tracked_at': '2026-04-27T12:03:36.882354'} |
| caption | CREB1 controls the unfolded protein response in MM. A Schema of the UPR signaling pathway. The UPR activates pro-apoptotic pathways when ER stress is prolonged, leading to the activation of BAX, BAK, |
| paper_id | 90da89f2-b9ac-4e5d-992a-d287f535e113 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC12811356/bin/41419_2025_8246_Fig3_HTML.jpg |
| image_path | |
| description | |
| figure_label | Fig. 3 |
| figure_number | 3 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
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Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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