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Fig. 6: Combi-ICI predisposes CNS to heightened autoimmune encephalomyelitis. Mice under...
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Created: 2026-04-22T18:07:41
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Fig. 6Figure 6
Combi-ICI predisposes CNS to heightened autoimmune encephalomyelitis. Mice underwent 3 weeks of combi-ICI treatment as described in Fig. 1 A. 72 h after the last Combi-ICI/Vehicle injection mice were randomly enrolled into active or adoptive transfer EAE groups. (A) Experimental Design showing induction of active or adoptive transfer EAE. (B) Daily mean clinical scores, day of onset, mean maximal score, and area under the curve (AUC) analysis showing onset, progression, and overall severity of active EAE. (C) Daily mean clinical scores, day of onset, mean maximal score, and area under the curve (AUC) analysis showing onset, progression, and overall severity of adoptive transfer EAE. All data are presented as mean ± SEM ( N = 12–32 mice per group). P values were derived from two-way ANOVA, Bonferroni’s multiple comparisons test, and One-tailed Mann-Whitney test
▸Metadata
| doi | 10.1186/s13046-025-03442-3 |
| pmcid | PMC12220143 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC12220143/bin/13046_2025_3442_Fig6_HTML.jpg', 'type': 'external', 'tracked_at': '2026-04-23T01:07:41.615533'} |
| caption | Combi-ICI predisposes CNS to heightened autoimmune encephalomyelitis. Mice underwent 3 weeks of combi-ICI treatment as described in Fig. 1 A. 72 h after the last Combi-ICI/Vehicle injection mice were |
| paper_id | ea6a2a97-b542-4b62-9f95-000231855b9e |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC12220143/bin/13046_2025_3442_Fig6_HTML.jpg |
| image_path | |
| description | |
| figure_label | Fig. 6 |
| figure_number | 6 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
📊 Evidence Profile
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Debates
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