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Figure 3 — Stress granules: Guardians of cellular health and triggers of disease.
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Created: 2026-04-21T18:29:40
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ID: paper-fig-paper-02b562b3f845-3
Figure 3Figure 3
Physiological and pathophysiological functions of stress granules (SGs). The illustration shows the various functions SGs play under physiological and pathophysiological conditions. SGs play a critical role in various biological processes, particularly in the regulation of mRNA translation. In germline cells, SGs protect maternal mRNA and maintain germline function through the formation of specific ribonucleoprotein (RNP) granules. SGs function as signaling hubs, impacting key pathways such as mitogen-activated protein kinase (MAPK), nuclear factor (NF)-κB, and p53, thereby regulating inflammation. SGs are also essential for viral defense, as they limit viral spread by responding to viral double-stranded RNA (dsRNA) and enhancing antiviral sensors that bolster immune responses. Recent pieces of evidence show that SGs regulate neuronal development, and defects in SG formation or clearance can lead to neurodevelopmental disorders (NDDs), neurodegeneration, and defective neural repair.
▸Metadata
| pmid | paper-02b562b3f845 |
| caption | Physiological and pathophysiological functions of stress granules (SGs). The illustration shows the various functions SGs play under physiological and pathophysiological conditions. SGs play a critica |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC12220703/bin/NRR-21-588-g003.jpg |
| paper_title | Stress granules: Guardians of cellular health and triggers of disease. |
| figure_label | Figure 3 |
| figure_number | 3 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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