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Fig. 7 — Potent and specific MTH1 inhibitors targeting gastric cancer.
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Created: 2026-04-21T18:29:40
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ID: paper-fig-paper-18d2a490986a-7
Fig. 7Figure 7
MTH1 suppression reduces the two gastric cancer cell survival. MGC-803, HGC-27 and GES-1 cells were treated by MTH1 specific siRNA#1 and #2 for 72 h. Non-targeting siRNA(NT) treatment was used as control. a Levels of MTH1 protein then were determined by western blot. b The colony formations were recorded after the cells were treated with MTH1 siRNA#1 and #2 for 7 days. c Western Blot analysis of the protein levels of MTH1, MUTYH, OGG1, p21, ATMpS1981 and p53pS15, after the cells were treated with siRNA#2. f – h Densitometry shows relative protein expression normalized by GAPDH. d The Alkaline comets assay was performed after the cells were transfected with MTH1 siRNA#2 for 72 h. Pictures were originally captured at ×40 magnification by fluorescence microscope. Non-targeting siRNA(NT) or H 2 O 2 treatment was used as a negative or a positive control, respectively. e Tail moment was calculated by CometScore software. Three individual experiments were performed for each group
▸Metadata
| pmid | paper-18d2a490986a |
| caption | MTH1 suppression reduces the two gastric cancer cell survival. MGC-803, HGC-27 and GES-1 cells were treated by MTH1 specific siRNA#1 and #2 for 72 h. Non-targeting siRNA(NT) treatment was used as cont |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC6547740/bin/41419_2019_1665_Fig7_HTML.jpg |
| paper_title | Potent and specific MTH1 inhibitors targeting gastric cancer. |
| figure_label | Fig. 7 |
| figure_number | 7 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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