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Fig. 2 — Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differe
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Created: 2026-04-21T18:29:40
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Fig. 2Figure 2
A: Volcano plot showing enrichment of lipid species of astrocyte immunopurified lipoprotein versus microglia immunopurified lipoprotein. Microglia ApoE lipoproteins are enriched in several CE species. Astrocyte ApoE lipoproteins are enriched in several SM species and FC. For lipidomics analysis, the following groups were analyzed: ApoE2 astrocytes (n = 6), ApoE3 astrocytes (n = 6), ApoE4 astrocytes (n = 6), ApoE2 microglia (n = 4), ApoE3 microglia (n = 4), and ApoE4 microglia (n = 4). B: PCA of the lipidome of ApoE lipoproteins shows partial separation of samples based on the cellular source of the ApoE lipoprotein but not by ApoE isoform. Circles represent the 95% confidence interval based on the cell type. C: Distribution of lipid classes by cell type shows the abundance of different lipid classes. The total amount of each lipid class is expressed as the nmol amount of protein per 1 mg of ApoE protein. The total amount of FC is significantly decreased in microglia ApoE lipoprotein (
▸Metadata
| pmid | paper-41692246 |
| caption | A: Volcano plot showing enrichment of lipid species of astrocyte immunopurified lipoprotein versus microglia immunopurified lipoprotein. Microglia ApoE lipoproteins are enriched in several CE species. |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC12996666/bin/gr2.jpg |
| paper_title | Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform. |
| figure_label | Fig. 2 |
| figure_number | 2 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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