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Extended Data Fig. 3 — TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocy
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Created: 2026-04-21T18:29:40
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Extended Data Fig. 3Figure 5
Identification of Mac1 subset in the septic heart, related to Fig. 2 . a, UMAP plots showing the expression of selected marker genes for the monocyte-macrophage subpopulations. b, Gating strategy to identified Mac1 cells (CD45 + CD11b + F4/80 + CD163 + RETNLA + ). c, Graph showing percentages of CD163 + RETNLA + cardiac macrophages during sepsis progression (SS, n = 8 mice; CLP 3 d, n = 8 mice; CLP 7 d, n = 9 mice; CLP 21 d, n = 10 mice). Each symbol represents one animal. Bars show mean ± SEM. Two-sided P values were determined by one-way ANOVA with Games-Howell’s multiple comparisons test. d, Representative immunofluorescence images showing the presence of CD163 (green), CD68 (red), and nuclei (blue) in cardiac tissues during sepsis progression. n = 6 mice per group. Scale bars, 20 μm. Exact P values are shown. Results represent four independent experiments (c,d). SS, steady state.
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▸Metadata
| pmid | paper-eec8991d7498 |
| caption | Identification of Mac1 subset in the septic heart, related to Fig. 2 . a, UMAP plots showing the expression of selected marker genes for the monocyte-macrophage subpopulations. b, Gating strategy to |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC9886554/bin/42255_2022_715_Fig10_ESM.jpg |
| paper_title | TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis. |
| figure_label | Extended Data Fig. 3 |
| figure_number | 5 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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