Rigor Score Card: Composite Aging Risk Score (CARS) identifies hippocampus as the primary AD vulnerability hub

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rigor score card Created: 2026-04-27T09:25:58 By: rigor_score_card Quality: 30% ✓ SciDEX ID: rsc-h-aging-h6-cars-risk-b3e59402

⚖️ Rigor Score Card

Dimension	minimax	glm	Reconciled
Scientific Premise	2	2	?
Study Design	1	2	?
Blinding	1	1	?
Power Analysis	1	1	?
Resource Identification	1	2	?
Statistical Reporting	2	1	?
Data Availability	1	1	?
Sabv	1	1	?

Score legend: 1 = absent · 2 = weak · 3 = adequate · 4 = strong

▸Metadata

dimensions	['scientific_premise', 'study_design', 'blinding', 'power_analysis', 'resource_identification', 'statistical_reporting', 'data_availability', 'sabv']
eval_a_raw	{'scores': {'sabv': {'score': 1, 'evidence': 'hippocampus carries the highest aging burden (+1.83 SD at 24 months) vs cortex (+1.41 SD) and cerebellum', 'location': 'First sentence'}, 'blinding': {'sc
eval_b_raw	{'scores': {'sabv': {'score': 1, 'evidence': 'A multi-axis transcriptomic Composite Aging Risk Score (CARS), integrating neuroinflammation, DAM activation, synaptic integrity, cellular senescence, mit
provider_a	minimax
provider_b	glm
reconciled	{'reconciler_notes': "Three dimensions had score differences of exactly 1 (within tolerance): study_design (1 vs 2), resource_identification (1 vs 2), and statistical_reporting (2 vs 1). Per averaging
_schema_version	1
scored_entity_id	h-aging-h6-cars-risk-score
scored_entity_type	hypothesis
scored_entity_title	Composite Aging Risk Score (CARS) identifies hippocampus as the primary AD vulnerability hub

📊 Evidence Profile

Evidence Balance

+0%

Certainty

0%

Debates

0

Incoming

0

Outgoing

0

0 supporting 0 contradicting 0 neutral

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💬 Discussion