Dataset Rankings

Introduction

This page ranks datasets for neurodegenerative disease research based on quality, accessibility, and scientific impact. [@adni2024]

Top Alzheimer's Disease Datasets

By Scientific Impact

| Rank | Dataset | Impact Score | Citations | Quality | [@ppmi2024]
|------|---------|--------------|-----------|---------| [@data2024]
| 1 | ADNI | 100 | 10,000+ | Very High |
| 2 | AMP-AD | 95 | 5,000+ | Very High |
| 3 | [ROS](/entities/reactive-oxygen-species)/MAP | 90 | 3,000+ | High |
| 4 | Religious Orders | 85 | 2,500+ | High |
| 5 | Mayo Clinic | 80 | 2,000+ | High |

By Accessibility

| Rank | Dataset | Access Score | Ease of Use |
|------|---------|--------------|-------------|
| 1 | ADNI | 95 | High |
| 2 | GWAS Catalog | 90 | Very High |
| 3 | AMP-AD | 70 | Moderate |
| 4 | ROS/MAP | 65 | Moderate |
| 5 | Banner | 60 | Moderate |

Top Parkinson's Disease Datasets

By Scientific Impact

| Rank | Dataset | Impact Score | Citations | Quality |
|------|---------|--------------|-----------|---------|
| 1 | PPMI | 100 | 5,000+ | Very High |
| 2 | AMP-PD | 90 | 1,500+ | Very High |
| 3 | MJFF | 80 | 1,000+ | High |
| 4 | PD Genetics | 85 | 2,000+ | High |
| 5 | NABEC | 70 | 500+ | Moderate |

By Scale

| Rank | Dataset | Sample Size | Data Types |
|------|---------|-------------|------------|
| 1 | PD Genetics | 50,000+ | Genetic |
| 2 | AMP-PD | 10,000+ | Multi-omics |
| 3 | PPMI | 2,000+ | Clinical, imaging |
| 4 | PD Brain Bank | 1,000+ | Tissue |

Top ALS Datasets

By Scientific Impact

Introduction

This page ranks datasets for neurodegenerative disease research based on quality, accessibility, and scientific impact. [@adni2024]

Top Alzheimer's Disease Datasets

By Scientific Impact

| Rank | Dataset | Impact Score | Citations | Quality | [@ppmi2024]
|------|---------|--------------|-----------|---------| [@data2024]
| 1 | ADNI | 100 | 10,000+ | Very High |
| 2 | AMP-AD | 95 | 5,000+ | Very High |
| 3 | [ROS](/entities/reactive-oxygen-species)/MAP | 90 | 3,000+ | High |
| 4 | Religious Orders | 85 | 2,500+ | High |
| 5 | Mayo Clinic | 80 | 2,000+ | High |

By Accessibility

| Rank | Dataset | Access Score | Ease of Use |
|------|---------|--------------|-------------|
| 1 | ADNI | 95 | High |
| 2 | GWAS Catalog | 90 | Very High |
| 3 | AMP-AD | 70 | Moderate |
| 4 | ROS/MAP | 65 | Moderate |
| 5 | Banner | 60 | Moderate |

Top Parkinson's Disease Datasets

By Scientific Impact

| Rank | Dataset | Impact Score | Citations | Quality |
|------|---------|--------------|-----------|---------|
| 1 | PPMI | 100 | 5,000+ | Very High |
| 2 | AMP-PD | 90 | 1,500+ | Very High |
| 3 | MJFF | 80 | 1,000+ | High |
| 4 | PD Genetics | 85 | 2,000+ | High |
| 5 | NABEC | 70 | 500+ | Moderate |

By Scale

| Rank | Dataset | Sample Size | Data Types |
|------|---------|-------------|------------|
| 1 | PD Genetics | 50,000+ | Genetic |
| 2 | AMP-PD | 10,000+ | Multi-omics |
| 3 | PPMI | 2,000+ | Clinical, imaging |
| 4 | PD Brain Bank | 1,000+ | Tissue |

Top ALS Datasets

By Scientific Impact

| Rank | Dataset | Impact Score | Citations | Quality |
|------|---------|--------------|-----------|---------|
| 1 | PRO-ACT | 95 | 2,000+ | Very High |
| 2 | Target ALS | 90 | 1,000+ | Very High |
| 3 | Project MinE | 85 | 1,500+ | Very High |
| 4 | NEALS | 80 | 800+ | High |
| 5 | ALS.net | 75 | 500+ | High |

By Data Richness

| Rank | Dataset | Data Types | Integration |
|------|---------|------------|-------------|
| 1 | Target ALS | Clinical, omics, tissue | Excellent |
| 2 | PRO-ACT | Clinical | Good |
| 3 | Project MinE | Genomics | Good |
| 4 | ALSGene | Genetic | Excellent |

Overall Rankings

Best Overall Datasets

| Rank | Dataset | Disease | Combined Score |
|------|---------|---------|----------------|
| 1 | ADNI | AD | 98 |
| 2 | PPMI | PD | 95 |
| 3 | AMP-AD | AD | 90 |
| 4 | AMP-PD | PD | 88 |
| 5 | PRO-ACT | ALS | 85 |

Most Underutilized

| Rank | Dataset | Disease | Potential |
|------|---------|---------|-----------|
| 1 | DIAN | AD | Very High |
| 2 | A4 Study | AD | High |
| 3 | SEPARATOR | PD | High |
| 4 | CNS Consortium | ALS | Moderate |

Data Quality Metrics

Quality Indicators

| Factor | Weight | Measurement |
|--------|--------|-------------|
| Sample size | 25% | Number of subjects |
| Data completeness | 25% | Missing data % |
| Longitudinal | 20% | Visit frequency |
| Multi-modal | 20% | Data types |
| Curation | 10% | QC standards |

Coverage Gaps

Missing Disease Categories

• FTD (Frontotemporal Dementia) - No dedicated FTD dataset rankings
• Huntington's Disease - Limited dataset representation
• MSA (Multiple System Atrophy) - No dedicated section
• PSP (Progressive Supranuclear Palsy) - Missing
• CBS (Corticobasal Syndrome) - Missing
• ALS/FTD Overlap - Datasets covering both conditions

Missing Major Datasets

• DIAN - Dominantly Inherited Alzheimer's Network (already mentioned as underutilized)
• A4 Study - Anti-Amyloid Treatment in Asymptomatic AD
• TOPMed - NHLBI Trans-Omics for Precision Medicine
• Gnemega - Genetic resource for neurological disorders
• iPSC Consortium - Induced pluripotent stem cell datasets

Dataset Integration Gaps

• Cross-dataset integration scores missing
• No unified data access API or integration roadmap
• Missing multi-ethnic representation data
• Lack of pediatric/neurodevelopmental datasets

Underrepresented Data Types

• Proteomics datasets - Limited coverage
• Metabolomics data - Missing from most rankings
• Single-cell datasets - Critical for cellular understanding
• Digital biomarker data - Emerging sensor data
• Real-world evidence - Clinical practice data

Priority Actions

Related Pages

• [Datasets Index](/datasets)
• [Dataset Overview](/datasets/overview)
• [Research Projects](/projects)

See Also

• [Alzheimer's Disease](/diseases/alzheimers-disease)
• [Parkinson's Disease](/diseases/parkinsons-disease)

External Links

• [PubMed](https://pubmed.ncbi.nlm.nih.gov/)
• [KEGG Pathways](https://www.genome.jp/kegg/pathway.html)

References