KCNE2
Overview
<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">KCNE2</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td>KCNE2</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>Potassium Voltage-Gated Channel Subfamily E Member 2</td>
</tr>
<tr>
<td class="label">Alias</td>
<td>MinK-Related Peptide 1 (MiRP1)</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>21q22.11</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>9993</td>
</tr>
<tr>
<td class="label">OMIM ID</td>
<td>603444</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000155974</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>Q9Y6H6</td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>
Kcne2 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Kcne2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@lee2018]
KCNE2 encodes a small single-pass transmembrane protein that functions as a regulatory subunit (beta subunit) for voltage-gated potassium channels, particularly the KCNQ1 (Kv7.1) channel. [@roepke2015]
...KCNE2
Overview
<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">KCNE2</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td>KCNE2</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>Potassium Voltage-Gated Channel Subfamily E Member 2</td>
</tr>
<tr>
<td class="label">Alias</td>
<td>MinK-Related Peptide 1 (MiRP1)</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>21q22.11</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>9993</td>
</tr>
<tr>
<td class="label">OMIM ID</td>
<td>603444</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000155974</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>Q9Y6H6</td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>
Kcne2 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Kcne2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@lee2018]
KCNE2 encodes a small single-pass transmembrane protein that functions as a regulatory subunit (beta subunit) for voltage-gated potassium channels, particularly the KCNQ1 (Kv7.1) channel. [@roepke2015]
Gene Overview
Function
KCNE2 (also known as MiRP1) encodes a 123-amino acid transmembrane protein that co-assembles with KCNQ1 (Kv7.1) alpha subunits to form cardiac IKr (rapid delayed rectifier) and IKs-like currents in various tissues [1](https://pubmed.ncbi.nlm.nih.gov/20385650/). Unlike KCNE1, KCNE2 produces channels with faster activation kinetics.
In the heart, the KCNQ1/KCNE2 complex contributes to ventricular repolarization. KCNE2 also assembles with other Kv channels, including hERG (KCNH2), modulating their gating properties.
In the brain, KCNE2 is expressed in various regions including [hippocampus](/brain-regions/hippocampus) and [cortex](/brain-regions/cortex), where it modulates neuronal excitability, though its central nervous system functions are less characterized.
Disease Associations
Long QT Syndrome and Cardiac Arrhythmias
KCNE2 variants are associated with long QT syndrome (LQT) and predispose to torsades de pointes, a potentially fatal polymorphic ventricular tachycardia [2](https://pubmed.ncbi.nlm.nih.gov/22113614/). KCNE2 mutations can also cause atrial fibrillation.
Alzheimer's Disease
Emerging research suggests KCNE2 may play a role in AD. The protein is expressed in brain regions affected by AD, and altered expression has been documented in AD models. KCNE2 may interact with [amyloid-beta](/proteins/amyloid-beta) to influence neuronal potassium homeostasis [3](https://pubmed.ncbi.nlm.nih.gov/23459194/).
Atrial Fibrillation
KCNE2 variants have been linked to atrial fibrillation, the most common sustained cardiac arrhythmia. The KCNQ1/KCNE2 current is important for atrial repolarization [4](https://pubmed.ncbi.nlm.nih.gov/26228151/).
Expression
KCNE2 is expressed in heart (especially atria), kidney, stomach, small intestine, and brain. In the brain, expression is detected in hippocampus, cortex, and cerebellum.
Therapeutic Implications
- Antiarrhythmic drug development: Targeting KCNE2-containing channels
- Atrial fibrillation treatment: Developing atrial-selective Kv channel modulators
- Neurodegeneration research: Understanding KCNE2's neuronal roles
Key Publications
[KCNE2 structure and function](https://pubmed.ncbi.nlm.nih.gov/20385650/) - PMID: 20385650(https://pubmed.ncbi.nlm.nih.gov/20385650/)
[KCNE2 and long QT syndrome](https://pubmed.ncbi.nlm.nih.gov/22113614/) - PMID: 22113614(https://pubmed.ncbi.nlm.nih.gov/22113614/)
[KCNE2 in neurodegenerative disease](https://pubmed.ncbi.nlm.nih.gov/23459194/) - PMID: 23459194(https://pubmed.ncbi.nlm.nih.gov/23459194/)
[KCNE2 and atrial fibrillation](https://pubmed.ncbi.nlm.nih.gov/26228151/) - PMID: 26228151(https://pubmed.ncbi.nlm.nih.gov/26228151/)See Also
- [Ion Channel Dysfunction](/mechanisms/ion-channel-dysfunction-neurodegeneration))
- [Potassium Channels](/entities/potassium-channels)
- [Long QT Syndrome](/diseases/long-qt-syndrome)
- [Alzheimer's Disease](/diseases/alzheimers-disease)
- [Atrial Fibrillation](/diseases/atrial-fibrillation)
- [Cardiac Arrhythmia](/diseases/cardiac-arrhythmia)
External Links
- [NCBI Gene: KCNE2](https://www.ncbi.nlm.nih.gov/gene/9993)
- [UniProt: Q9Y6H6](https://www.uniprot.org/uniprot/Q9Y6H6)
- [Ensembl: ENSG00000155974](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000155974)
- [Human Protein Atlas: KCNE2](https://www.proteinatlas.org/genes/KCNE2)
Overview
Kcne2 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Background
The study of Kcne2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
References
[Abbott GW, KCNE2 and cardiac electrical function (2019)](https://pubmed.ncbi.nlm.nih.gov/31054326/)
[Unknown, Lee JH, Vanhoutte PM, B帮ee S. KCNE2 in gastric epithelial cells and acid secretion (2018)](https://pubmed.ncbi.nlm.nih.gov/28778922/)
[Roepke TK, Purtell K, Kanda VA, et al, Targeted deletion of Kcne2 causes gastric pathology (2015)](https://pubmed.ncbi.nlm.nih.gov/25865003/)
[Malas TB, Stapleton PC, McGettigan PA, et al, KCNE2 variants in epilepsy (2020)](https://pubmed.ncbi.nlm.nih.gov/33185219/)