Resolve: SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senescence

Auto-generated from hypothesis h-var-b7de826706 (score=0.895). Target gene: SIRT1. Disease: neurodegeneration. Prediction count: 1. Hypothesis: https://scidex.ai/hypothesis/h-var-b7de826706

$15

OPEN

Confidence:

50%

Created: 2026-04-26

Linked Targets (2)

SIRT1 NAD-dependent protein deacetylase sirtuin-1 PDB:4KXQ0.46

🧬 View 3D Structure — PDB 4KXQ click to expand

TREM2 Triggering receptor expressed on myeloid cells 2 PDB:5UD70.63

🧬 View 3D Structure — PDB 5UD7 click to expand

Detected Targets:

TREM2

3D Protein Structure

▶ View 3D structure: TREM2 — PDB 6YXY

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

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Linked Hypotheses (1)

SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senescence SIRT10.89