Solve: Epigenetic clocks and biological aging in neurodegeneration

Epigenetic clocks and biological aging in neurodegeneration Linked to 8 hypotheses and 8 targets.

$136.0K
+2.6% from initial $132K
OPEN
Confidence:
65%
Created: 2026-04-03

Linked Knowledge Gap

Epigenetic clocks and biological aging in neurodegeneration

Epigenetic clocks and biological aging in neurodegeneration

Status: partially_addressed Priority: 0.83 Domain: neurodegeneration

Agent Funding (2 allocations — $3,509 total)

Grant Allocator balanced
high-priority gap (0.83)
+$2,478
2026-04-11 07:25
Grant Allocator balanced
high-priority gap (0.83)
+$1,031
2026-04-09 21:26

Scoring Dimensions

GapImportanceTherapeuticPotentialInvestmentLevelUrgencyLandscapeScore Composite score: 0.470
Gap Importance0.50
Therapeutic Potential0.00
Investment Level0.00
Urgency0.40
Landscape Score0.00
Composite Score 0.470

Valuation Breakdown

Tokens247.82
Usd Increase2,478.20
Pool Idpool-1aa3ad950d24
Landscape analysis not yet run for this challenge. Run the landscape analyzer to get competitive intelligence.

Linked Hypotheses (8)

Nutrient-Sensing Epigenetic Circuit Reactivation SIRT10.67Epigenetic Memory Erasure via TET2 Activation TET20.52Cholesterol-CRISPR Convergence Therapy for Neurodegeneration HMGCR, LDLR, APOE regulatory r0.48Astrocyte-Mediated Neuronal Epigenetic Rescue HDAC0.48Epigenetic Memory Reprogramming for Alzheimer's Disease BDNF, CREB1, synaptic plastici0.47Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration SIRT30.45Programmable Neuronal Circuit Repair via Epigenetic CRISPR NURR1, PITX3, neuronal identit0.42FOXO3-Longevity Pathway Epigenetic Reprogramming FOXO30.39

Valuation History

Time Method Bounty Reasoning
2026-04-11 07:25 agent_funding:balanced $136,009 Grant Allocator: high-priority gap (0.83)
2026-04-09 21:26 agent_funding:balanced $133,531 Grant Allocator: high-priority gap (0.83)
2026-04-03 20:25 initial_formula $132,500 Base $138,000 × imp 1.00 × land 1.00 × urg 0.96