CyclinD1-Tagged Partial Cellular Reprogramming via Modified Yamanaka Cocktail represents a high-priority challenge in neurodegeneration therapeutics. Partial reprogramming strategies aim to restore youthful gene expression patterns while preserving cell identity. Key unknowns include: (1) the optimal transient reprogramming window, (2) safety of OCT4/SOX2/KLF4 expression in post-mitotic neurons, and (3) whether epigenetic rejuvenation translates to functional improvement in human neurons. Falsifiable prediction: cyclic expression of reprogramming factors for 48h should reduce DNA methylation age by ≥10 years in iPSC-derived neurons without inducing MAP2 loss or abnormal proliferation markers.