OCT4

OCT4 Protein

Score: 0.360 Price: $0.36 Undruggable Druggability Status: active

HYPOTHESES

PAPERS

KG EDGES

DEBATES

3D Protein Structure

🧬 OCT4 — PDB 3L1P Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability

Undruggable

Score: 0.23

Clinical Stage

Preclinical

Target Class

Protein

Safety

0.50

Druggability Analysis

Drug Development0.00

Structural Tractability0.30

Target Class0.50

Safety Profile0.50

Key Metrics

PDB Structures:

Known Drugs:

Approved:

In Clinical Trials:

Drug Pipeline (1 compounds)

1 Preclinical

Mechanism: Prioritized from 1 SciDEX hypotheses, including: Partial Neuronal Reprogramming via Modified Yamanaka Cocktail

Drug Pipeline (1 compounds)

1 Preclinical

Known Drugs:

CHEMBL5797734 (preclinical)

Structural Data:

PDB —AlphaFold ✓Cryo-EM —

UniProt: Q01860

🧬 3D Protein Structure

🧬 OCT4 — PDB 3L1P Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

3D Protein Structure (AlphaFold)

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AlphaFold predicted structure available for Q01860

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Linked Hypotheses (1)

Partial Neuronal Reprogramming via Modified Yamanaka Cocktail0.672

Linked Experiments (0)

No linked experiments

Scoring Dimensions

Knowledge Graph (20)

activates (9)

OCT4→cellular_reprogrammingOCT4→POU5F1OCT4→SOX2OCT4→KLF4OCT4→DNMT3A

▸ Show 4 more

OCT4→PluripotencyPOU5F1→OCT4KLF4→OCT4DNMT3A→OCT4

Debate History (1)

Should OCT4 (OCT4 Protein) be prioritized as a therapeutic target for neurodegen2026-04-26

OCT4

3D Protein Structure

Druggability & Clinical Context

🧬 3D Protein Structure

3D Protein Structure (AlphaFold)

Linked Hypotheses (1)

Linked Experiments (0)

Scoring Dimensions

Knowledge Graph (20)

activates (9)

biomarker for (5)

interacts with (1)

involved in (1)

regulates (3)

therapeutic target (1)

Debate History (1)