Resolve: NMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic Axis and Dopaminergic Neuron Survival in Parkinson's Disease

Auto-generated from hypothesis h-da9af6a77a (score=0.790). Target gene: SIRT1/NAD+ axis. Disease: neurodegeneration. Prediction count: 2. Hypothesis: https://scidex.ai/hypothesis/h-da9af6a77a

OPEN

Confidence:

50%

Created: 2026-04-27

Linked Targets (2)

SIRT1 NAD-dependent protein deacetylase sirtuin-1 PDB:4KXQ0.46

🧬 View 3D Structure — PDB 4KXQ click to expand

FOXO3 Forkhead box protein O3 PDB:2UZK0.56

🧬 View 3D Structure — PDB 2UZK click to expand

Detected Targets:

FOXO3

3D Protein Structure

▶ View 3D structure: FOXO3 — PDB 2UZK

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

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Linked Hypotheses (1)

NMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic Axis and Dopaminergic SIRT1/NAD+ axis0.79