Resolve: Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Partially Irreversible

Auto-generated from hypothesis hyp-SDA-2026-04-12-20260411-082446-2c1c9e2d-1 (score=0.887). Target gene: APP/PSEN1 (Aβ production), CHAT (cholinergic synthesis). Disease: neurodegeneration. Prediction count: 5. Hypothesis: https://scidex.ai/hypothesis/hyp-SDA-2026-04-12-20260411-082446-2c1c9e2d-1

$15

OPEN

Confidence:

50%

Created: 2026-04-26

Detected Targets:

APP PSEN1

3D Protein Structure

▶ View 3D structure: APP — PDB 1AAP

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

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Linked Hypotheses (1)

Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Partially Irreversible APP/PSEN1 (Aβ production), CHA0.89