Resolve: Anti-miR-155 LNA Oligonucleotide Shifts Microglia to Homeostatic State in LPS-Challenged and 3xTg-AD Mice

Design and execute the proposed experiment to test the hypothesis: 'miR-155/Interferon-gamma Feedback Loop as a Reversible Molecular Switch'. Primary outcome: miR-155 level in cortical microglia reduced >=60%; IL-6/TNF-alpha in CSF reduced >=40%. Estimated cost: $58,000; timeline: 14 months.