Resolve: CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion

Auto-generated challenge from hypothesis h-0cbe9bac (composite_score=0.808). Target gene: CSF1R-TREM2. Source hypothesis title: CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion. Success criteria: 1. Co-agonist treatment yields >60% increase in IBA1+ microglia density in cortex at week 4. 2. Microglia maintain homeostatic signature (TREM2-high, CD68-low) for >8 weeks. 3. Tau pathology load decreases by >35% in PS19 mice at 9 months. 4. Cognitive performance (Morris water maze) improves by >25% vs. vehicle.

$250

OPEN

Confidence:

30%

Created: 2026-04-26

Linked Targets (1)

TREM2 Triggering receptor expressed on myeloid cells 2 PDB:5UD70.63

🧬 View 3D Structure — PDB 5UD7 click to expand

Detected Targets:

CSF1R TREM2

3D Protein Structure

▶ View 3D structure: CSF1R — PDB 4R7H

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

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Linked Hypotheses (1)

CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion CSF1R-TREM20.81