gene

CSF1R

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CSF1R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

586Connections

1Hypotheses

5Analyses

50Outgoing

50Incoming

Summary

Gene profile: CSF1R — Colony Stimulating Factor 1 Receptor

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🧬 Gene Info

Gene Symbol	CSF1R
Full Name	Colony Stimulating Factor 1 Receptor
Chromosome	5q32
Protein Type	Receptor
Function	Upon ligand binding, CSF1R undergoes
Primary Expression	Microglia, Macrophages, Osteoclasts, Placenta
Molecular Weight	107.6 kDa
Amino Acids	972 aa
Pathways	PI3K
UniProt ID	P07333
NCBI Gene ID	1436
Ensembl ID	ENSG00000182578
OMIM	164770
GeneCards	CSF1R
Human Protein Atlas	CSF1R
Associated Diseases	ALS, Alzheimer, Anxiety, Atherosclerosis, CSF1R-related Leukoencephalopathy
Known Drugs/Compounds	KETAMINE, NICOTINAMIDE, PLX3397, PLX5622, nicotinamide, dasatinib
Interactions	STAT5, MECP2, JAK2, PDGFRB, BDNF, CX3CR1
KG Connections	586 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure: CSF1R — PDB 4R7H Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CSF1R["CSF1R"]
    CSF1R -->|"regulates"| microglia["microglia"]
    CSF1R -->|"activates"| Leukemia["Leukemia"]
    CSF1R -->|"activates"| Als["Als"]
    CSF1R -->|"activates"| Ms["Ms"]
    CSF1R -->|"inhibits"| Depression["Depression"]
    CSF1R -->|"activates"| Carcinoma["Carcinoma"]
    CSF1R -->|"activates"| Cancer["Cancer"]
    CSF1R -->|"activates"| Tumor["Tumor"]
    PLX3397["PLX3397"] -->|"inhibits"| CSF1R
    dasatinib["dasatinib"] -->|"inhibits"| CSF1R
    PLX5622["PLX5622"] -->|"inhibits"| CSF1R
    TYK2["TYK2"] -->|"contributes to"| CSF1R
    PTK2B["PTK2B"] -->|"contributes to"| CSF1R
    IL7R["IL7R"] -->|"contributes to"| CSF1R
    JAK2["JAK2"] -->|"activates"| CSF1R
    PDGFRB["PDGFRB"] -->|"activates"| CSF1R
    ETV6["ETV6"] -->|"expressed in"| CSF1R
    NTRK3["NTRK3"] -->|"contributes to"| CSF1R

Outgoing (383)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
CSF1R-related Leukoencephalopathy	causes	disease	0.95
SOLUBLE CSF1R	cleaves	protein	0.85
Microglial Activation	modulates	process	0.85
Alzheimer'S	therapeutic_target	disease	0.85
neurons	expressed_in	cell_type	0.85
Immune Cell Infiltration	associated_with	process	0.80
tumor-associated macrophages	regulates	cell_type	0.80
neurodegeneration	inhibits	disease	0.80
neuroinflammation	activates	disease	0.75
neuroinflammation	inhibits	disease	0.75
Als	activates	disease	0.75
astrocytes	expressed_in	cell_type	0.75
TAU	inhibits	protein	0.70
COMPLEMENT PATHWAY	inhibits	pathway	0.70
Schwann cells	expressed_in	cell_type	0.70
Blood-Brain Barrier	activates	pathway	0.70
microglia	regulates	cell_type	0.70
MICROGLIA	inhibits	gene	0.70
microglia	expressed_in	cell_type	0.70
NICOTINAMIDE	inhibits	drug	0.70
stem cells	expressed_in	cell_type	0.70
TAU	associated_with	gene	0.65
TREM2	associated_with	gene	0.65
PARP1	associated_with	gene	0.65
JNK	activates	gene	0.65
PI3K	activates	gene	0.65
JNK	phosphorylates	gene	0.65
PI3K	phosphorylates	gene	0.65
PI3K	causes	gene	0.65
neurotrophin signaling	participates_in	pathway	0.65
TAU	treats	protein	0.65
GFAP	regulates	gene	0.65
Leukemia	activates	disease	0.65
Ms	activates	disease	0.65
Ms	inhibits	disease	0.65
Depression	inhibits	disease	0.65
NEUROINFLAMMATION	associated_with	concept	0.65
NEURON	associated_with	gene	0.65
Carcinoma	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
ALS	activates	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Als	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Stroke	activates	disease	0.65
Inflammation	activates	disease	0.65

Incoming (203)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
PLX3397	inhibits	drug	0.90
h-var-799795f6af	targets_gene	hypothesis	0.90
MICROGLIA	associated_with	cell_type	0.74
dasatinib	inhibits	drug	0.72
PLX5622	inhibits	drug	0.70
PARP1	inhibits	gene	0.70
BDNF	associated_with	gene	0.66
AMYLOID	associated_with	gene	0.66
CD2AP	activates	gene	0.65
BAX	treats	gene	0.65
ASTROCYTE	associated_with	gene	0.65
CANCER	associated_with	disease	0.65
NEUROINFLAMMATION	treats	phenotype	0.65
MACROPHAGE	interacts_with	cell_type	0.65
NEURONS	treats	cell_type	0.65
NEURONS	inhibits	cell_type	0.65
MACROPHAGES	produces	cell_type	0.65
ASTROCYTE	activates	cell_type	0.65
MICROGLIA	regulates	cell_type	0.65
ALZHEIMER'S DISEASE	associated_with	disease	0.64
TYK2	contributes_to	gene	0.60
PTK2B	contributes_to	gene	0.60
IL7R	contributes_to	gene	0.60
JAK2	activates	gene	0.60
PDGFRB	activates	gene	0.60
NTRK3	contributes_to	gene	0.60
NRBP1	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
HNRNPU	activates	gene	0.60
MYC	activates	gene	0.60
CSF1	therapeutic_target	gene	0.60
CTCF	therapeutic_target	gene	0.60
EP300	activates	gene	0.60
IGF2BP2	therapeutic_target	gene	0.60
ARG1	activates	gene	0.60
NLRP3	activates	gene	0.60
LGALS3	expressed_in	gene	0.60
CD44	expressed_in	gene	0.60
SESN3	expressed_in	gene	0.60
ATG7	expressed_in	gene	0.60
JNK	activates	gene	0.60
RAMP1	associated_with	gene	0.60
C1QB	associated_with	gene	0.60
TYROBP	associated_with	gene	0.60
CCR1	associated_with	gene	0.60
CD4	associated_with	gene	0.60
AIF1	associated_with	gene	0.60
CD163	associated_with	gene	0.60
CYBB	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming	0.589	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (5)

Scientific analyses that reference this entity

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.670

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 49 hypotheses Top: 0.709

TDP-43 phase separation therapeutics for ALS-FTD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.575

4R-tau strain-specific spreading patterns in PSP vs CBD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.507

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CSF1R

Understanding Entity Pages

Summary

Wiki Pages (21)

CSF1R — Colony Stimulating Factor 1 Receptor

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