gene

CSF1R

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CSF1R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

704Connections

10Hypotheses

17Analyses

50Outgoing

50Incoming

0Experiments

20Debates

Summary

Gene profile: CSF1R — Colony Stimulating Factor 1 Receptor

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	CSF1R
Full Name	Colony Stimulating Factor 1 Receptor
Chromosome	5q32
Protein Type	Receptor
Function	Upon ligand binding, CSF1R undergoes
Primary Expression	Microglia, Macrophages, Osteoclasts, Placenta
Molecular Weight	107.6 kDa
Amino Acids	972 aa
Pathways	PI3K
UniProt ID	P07333
NCBI Gene ID	1436
Ensembl ID	ENSG00000182578
OMIM	164770
GeneCards	CSF1R
Human Protein Atlas	CSF1R
Associated Diseases	Als, Alzheimer, Anxiety, Atherosclerosis, cancer
Known Drugs/Compounds	dasatinib, KETAMINE, nicotinamide, NICOTINAMIDE, PLX3397, PLX5622
Interactions	ABL1, ABL2, ACHE, ACT001, Actin, AD
SciDEX Hypotheses	TREM2-Independent Microglial Activation via CSF1R CSF1R Inhibition-Mediated Microglial Replacement a CSF1R Agonism for TREM2-Independent Microglial Act (+1 more)
KG Connections	704 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — CSF1R Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

4R7H — X-ray / Cryo-EM

🔮 AI Predicted Structure

P07333 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CSF1R["CSF1R"]
    CSF1R -->|"regulates"| microglia["microglia"]
    CSF1R -->|"activates"| Leukemia["Leukemia"]
    CSF1R -->|"activates"| Als["Als"]
    CSF1R -->|"activates"| Ms["Ms"]
    CSF1R -->|"inhibits"| Depression["Depression"]
    CSF1R -->|"activates"| Carcinoma["Carcinoma"]
    CSF1R -->|"activates"| Cancer["Cancer"]
    CSF1R -->|"activates"| Tumor["Tumor"]
    PLX3397["PLX3397"] -->|"inhibits"| CSF1R
    dasatinib["dasatinib"] -->|"inhibits"| CSF1R
    PLX5622["PLX5622"] -->|"inhibits"| CSF1R
    TYK2["TYK2"] -->|"contributes to"| CSF1R
    PTK2B["PTK2B"] -->|"contributes to"| CSF1R
    IL7R["IL7R"] -->|"contributes to"| CSF1R
    JAK2["JAK2"] -->|"activates"| CSF1R
    PDGFRB["PDGFRB"] -->|"activates"| CSF1R
    ETV6["ETV6"] -->|"expressed in"| CSF1R
    NTRK3["NTRK3"] -->|"contributes to"| CSF1R

Outgoing (464)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CSF1R	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
CSF1R-related Leukoencephalopathy	causes	disease	0.95
Alzheimer'S	therapeutic_target	disease	0.85
neurons	expressed_in	cell_type	0.85
Microglial Activation	modulates	process	0.85
SOLUBLE CSF1R	cleaves	protein	0.85
tumor-associated macrophages	regulates	cell_type	0.80
neurodegeneration	inhibits	disease	0.80
Immune Cell Infiltration	associated_with	process	0.80
Als	activates	disease	0.75
neuroinflammation	inhibits	disease	0.75
neuroinflammation	activates	disease	0.75
astrocytes	expressed_in	cell_type	0.75
PDGF	expressed_in	gene	0.70
IBA1	activates	gene	0.70
STING	causes	gene	0.70
MICROGLIA	protects_against	cell_type	0.70
CX3CR1	markers	gene	0.70
CX3CR1	activates	gene	0.70
LAMP1	activates	gene	0.70
JAK	activates	gene	0.70
ULK1	activates	gene	0.70
MACROPHAGE	expresses	cell_type	0.70
MICROGLIA	mediates	cell_type	0.70
NEURONS	mediates	cell_type	0.70
PDGF	associated_with	gene	0.70
MACROPHAGE	markers	cell_type	0.70
CXCL10	inhibits	gene	0.70
STING	activates	gene	0.70
SQSTM1	activates	gene	0.70
microglial_activation	regulates	phenotype	0.70
neuroinflammation	regulates	phenotype	0.70
Microglial activation	regulates	mechanism	0.70
MICROGLIA	inhibits	gene	0.70
Blood-Brain Barrier	activates	pathway	0.70
microglia	regulates	cell_type	0.70
APOE4 effects	inhibits	pathway	0.70
TAU	inhibits	protein	0.70
COMPLEMENT PATHWAY	inhibits	pathway	0.70
NICOTINAMIDE	inhibits	drug	0.70
Schwann cells	expressed_in	cell_type	0.70
microglia	expressed_in	cell_type	0.70
stem cells	expressed_in	cell_type	0.70
PI3K	activates	gene	0.65
JNK	activates	gene	0.65
Stroke	activates	disease	0.65
Inflammation	inhibits	disease	0.65
TREM2	associated_with	gene	0.65
Neuroinflammation	activates	disease	0.65

Incoming (240)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CSF1R	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
h-var-799795f6af	targets_gene	hypothesis	0.90
PLX3397	inhibits	drug	0.90
TREM2	co-stimulates	gene	0.87
SYK	cooperates_with	gene	0.85
TREM2	co-expressed_with	gene	0.85
MICROGLIA	associated_with	cell_type	0.74
dasatinib	inhibits	drug	0.72
APP	activates	gene	0.70
ATG5	activates	gene	0.70
APOE	activates	gene	0.70
BECN1	activates	gene	0.70
AIF1	activates	gene	0.70
PLX5622	inhibits	drug	0.70
PARP1	inhibits	gene	0.70
AMYLOID	associated_with	gene	0.66
BDNF	associated_with	gene	0.66
ASTROCYTE	activates	cell_type	0.65
CD2AP	activates	gene	0.65
CANCER	associated_with	disease	0.65
MICROGLIA	regulates	cell_type	0.65
MACROPHAGE	interacts_with	cell_type	0.65
NEUROINFLAMMATION	treats	phenotype	0.65
ASTROCYTE	associated_with	gene	0.65
BAX	treats	gene	0.65
NEURONS	treats	cell_type	0.65
NEURONS	inhibits	cell_type	0.65
MACROPHAGES	produces	cell_type	0.65
ALZHEIMER'S DISEASE	associated_with	disease	0.64
IL-1	activates	gene	0.60
BDNF	inhibits	gene	0.60
NLRP3	activates	gene	0.60
CD86	associated_with	gene	0.60
BRAIN INJURY	activates	gene	0.60
ASTROCYTE	inhibits	gene	0.60
DNA	inhibits	gene	0.60
DEPRESSION	inhibits	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
COMPLEMENT	associated_with	gene	0.60
AGING	activates	gene	0.60
EXERCISE	activates	gene	0.60
GFP	activates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
HDAC	activates	gene	0.60
STROKE	activates	gene	0.60
NRBP1	inhibits	gene	0.60
COX2	expressed_in	gene	0.60

Targeting Hypotheses (10)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion	0.808	neurodegeneration	TREM2 agonism vs antagonism in DAM micro
TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming	0.748	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Independent Microglial Activation via CSF1R	0.659	neurodegeneration	Methodology challenge: dataset 'Allen Br
CSF1R Inhibition-Mediated Microglial Replacement as a State	0.581	neurodegeneration	How do different microglial subtypes (DA
CSF1R Partial Agonism Combined with TREM2 Activation for ALS	0.535	neurodegeneration	Microglial subtypes in neurodegeneration

TREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1	0.496	neurodegeneration	How do perivascular cells specifically r
CSF1R Agonism for TREM2-Independent Microglial Activation in	0.445	neurodegeneration	Test
CSF1R Inhibition Reversal Window Depends on Microglia Replac	0.395	neurodegeneration	What is the optimal therapeutic window f
Microglial Phenotypic Polarization via CSF1R-Mediated Metabo	0.380	developmental-neurobiology	Do perinatal immune challenges create pe
Phagocytic Receptor (CSF1R)-Mediated Uptake of Circadian-Mod	0.000	-	Can circadian interventions selectively

Mentioning Analyses (17)

Scientific analyses that reference this entity

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

neurodegeneration | 2026-04-28 | 7 hypotheses Top: 0.662

TREM2 in Alzheimer's Disease: Mechanisms, Therapeutics, and Biomarkers

neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.861

Does Alectinib truly bind C1q directly with high affinity, or is this an experim

molecular biology | 2026-04-17 | 10 hypotheses Top: 0.445

Microglial subtypes in neurodegeneration — friend vs foe

neurodegeneration | 2026-04-17 | 7 hypotheses Top: 0.685

How do different microglial subtypes (DAM vs inflammatory vs homeostatic) transi

neurodegeneration | 2026-04-16 | 4 hypotheses Top: 0.887

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (11)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Dynamics and Impact of Repopulating Microglia Following Oligodendroglial Damage. [PMID:41645884]	Di Pietro AA, Thomas L, Pasquini LA	J Neurochem	2026
Temporal modulation of microglial repopulation attenuates retinal degeneration i [PMID:41690604]	Zhang W, Bian B, Ren C	Neurobiol Dis	2026
The impact of CSF1R inhibitor-mediated microglial depletion in rodent models of [PMID:41822299]	Ferreira AFF, Santos-Silva AC, Muratori	Front Aging Neurosci	2026
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model w [PMID:34103079]	["Lodder Chritica", "Scheyltjens Isabell	Acta neuropathologica communic	2021
Don't know what you got till it's gone: microglial depletion and neurodegenerati [PMID:33642360]	["Graykowski David", "Cudaback Eiron"]	Neural regeneration research	2021
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Microglial Depletion with CSF1R Inhibitor During Chronic Phase of Experimental T [PMID:32094203]	["Henry Rebecca J", "Ritzel Rodney M", "	The Journal of neuroscience :	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018

Debates (20)

Multi-agent debates referencing this entity

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

closed · Rounds: 4 · Score: 0.76 · 2026-04-28

Extended debate: TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegenera

closed · Rounds: 6 · Score: 0.95 · 2026-04-27

Extended debate: Closed-loop transcranial focused ultrasound with 40Hz gamma ent

closed · Rounds: 6 · Score: 0.95 · 2026-04-27

Extended debate: Closed-loop tACS targeting EC-II SST interneurons to block tau

closed · Rounds: 6 · Score: 0.95 · 2026-04-27

Debate: Closed-loop transcranial focused ultrasound targeting entorhinal PV inte

closed · Rounds: 4 · Score: 0.65 · 2026-04-27

Debate: Chromatin Remodeling-Mediated Nutrient Sensing Restoration

closed · Rounds: 4 · Score: 0.46 · 2026-04-27

Debate: Closed-loop tACS targeting EC-II SST interneurons to block tau propagati

closed · Rounds: 4 · Score: 0.71 · 2026-04-27

Debate: Closed-loop transcranial focused ultrasound to restore hippocampal gamma

closed · Rounds: 4 · Score: 0.87 · 2026-04-27

Debate: Closed-loop tACS targeting EC-II PV interneurons to suppress burst firin

closed · Rounds: 4 · Score: 0.48 · 2026-04-27

Debate: Closed-loop tACS targeting EC-II somatostatin interneurons to restore de

closed · Rounds: 4 · Score: 0.54 · 2026-04-27

Related Research

Hypotheses and analyses mentioning CSF1R in their description or question text

TREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1 Upregulation Through

Score: 0.496 · neurodegeneration · 2026-04-22

## Mechanistic Overview TREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1 Upregulation Through CSF1R-Mediated

CSF1R Agonism for TREM2-Independent Microglial Activation in ALS

Score: 0.445 · neurodegeneration · 2026-05-10

Proposed CSF1R agonism to activate neuroprotective microglial states avoiding TREM2-dependent inflammation. Fatal mechan

CSF1R Inhibition Reversal Window Depends on Microglia Replacement Kinetics

Score: 0.395 · neurodegeneration · 2026-04-22

## Mechanistic Overview CSF1R Inhibition Reversal Window Depends on Microglia Replacement Kinetics starts from the claim

Microglial Phenotypic Polarization via CSF1R-Mediated Metabolic Reprogramming

Score: 0.380 · developmental-neurobiology · 2026-04-27

The molecular foundation of microglial phenotypic polarization during perinatal immune activation centers on colony-stim

Phagocytic Receptor (CSF1R)-Mediated Uptake of Circadian-Modifying Peptides

Score: 0.000 · unknown disease · 2026-04-28

CSF1R mediates microglial proliferation and survival. CSF1R-targeted peptide conjugates incorporating circadian-modifyin

CSF1R

Understanding Entity Pages

Summary

Wiki Pages (11)

CSF1R — Colony Stimulating Factor 1 Receptor

Validated Hypothesis: CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion

CSF1R Inhibitors for Parkinson's Disease

CSF1R-Targeted Microglia Therapy

Pexidartinib (PLX3397) CSF1R Inhibitor Parkinson's Disease Trial (NCT04888966)

CSF1R Modulation Therapy: Microglia Reset Protocol

CSF1R Inhibitors for Neurodegeneration

CSF1R Modulation Therapy

CSF1R Protein (Colony Stimulating Factor 1 Receptor)

PLX5622 CSF1R Inhibitor Trial in Early Alzheimer's Disease

CSF1R-Inhibited Microglia

Pathway Diagram

Outgoing (464)

Incoming (240)

Targeting Hypotheses (10)

Mentioning Analyses (17)

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

TREM2 in Alzheimer's Disease: Mechanisms, Therapeutics, and Biomarkers

Does Alectinib truly bind C1q directly with high affinity, or is this an experim

Microglial subtypes in neurodegeneration — friend vs foe

How do different microglial subtypes (DAM vs inflammatory vs homeostatic) transi

How do B cells mechanistically orchestrate tolerance to AQP4 and prevent autoimm

How do perivascular cells specifically recognize and respond to amyloid-β to upr

Epigenetic reprogramming in aging neurons

Neuroinflammation and microglial priming in early AD

Neuroinflammation and microglial priming in early Alzheimer's Disease

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Circuit-level neural dynamics in neurodegeneration

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

TDP-43 phase separation therapeutics for ALS-FTD

4R-tau strain-specific spreading patterns in PSP vs CBD

TREM2 agonism vs antagonism in DAM microglia

Mitochondrial transfer between neurons and glia

Experiments (0)

Related Papers (11)

Debates (20)

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

Extended debate: TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegenera

Extended debate: Closed-loop transcranial focused ultrasound with 40Hz gamma ent

Extended debate: Closed-loop tACS targeting EC-II SST interneurons to block tau

Debate: Closed-loop transcranial focused ultrasound targeting entorhinal PV inte

Debate: Chromatin Remodeling-Mediated Nutrient Sensing Restoration

Debate: Closed-loop tACS targeting EC-II SST interneurons to block tau propagati

Debate: Closed-loop transcranial focused ultrasound to restore hippocampal gamma

Debate: Closed-loop tACS targeting EC-II PV interneurons to suppress burst firin

Debate: Closed-loop tACS targeting EC-II somatostatin interneurons to restore de

Related Research

TREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1 Upregulation Through

CSF1R Agonism for TREM2-Independent Microglial Activation in ALS

CSF1R Inhibition Reversal Window Depends on Microglia Replacement Kinetics

Microglial Phenotypic Polarization via CSF1R-Mediated Metabolic Reprogramming

Phagocytic Receptor (CSF1R)-Mediated Uptake of Circadian-Modifying Peptides