RBM45,GSK3B,TDP-43,TARDBP,hnRNP A1,HNRNPA1,phase separation,Liquid droplet · als · mechanistic
Composite 0.868
Price $0.73
Evidence For 0
Evidence Against 0
RBM45 (RNA Binding Motif Protein 45) is a predominantly neuronal RNA-binding protein that undergoes ALS-associated disease modifications (phosphorylation, oxidative modification) that alter its liquid-liquid phase separation (LLPS) behavior. This hypothesis proposes that in ALS motor neurons, modified RBM45 forms aberrant, stable condensates that dominate RNA processing droplets (nuclear speckles, stress granules), displacing essential granule components (SFPQ, TDP-43, hnRNP A1) into a pathologi
Radar Chart — 10 Dimensions
Score Comparison Bars
Mechanistic
0.72
Evidence
0.75
Novelty
0.82
Feasibility
0.68
Impact
0.78
Druggability
0.00
Safety
0.00
Competition
0.00
Data
0.00
Reproducible
0.00
KG Connect
0.50
Score Breakdown
Dimension
RBM45 Liquid-Liquid Phase Sepa
Mechanistic
0.720
Evidence
0.750
Novelty
0.820
Feasibility
0.680
Impact
0.780
Druggability
0.000
Safety
0.000
Competition
0.000
Data
0.000
Reproducible
0.000
KG Connect
0.500
Evidence
RBM45 Liquid-Liquid Phase Separation Dominance Hijacks RNA P