RBM45 (RNA Binding Motif Protein 45) is a predominantly neuronal RNA-binding protein that undergoes ALS-associated disease modifications (phosphorylation, oxidative modification) that alter its liquid-liquid phase separation (LLPS) behavior. This hypothesis proposes that in ALS motor neurons, modified RBM45 forms aberrant, stable condensates that dominate RNA processing droplets (nuclear speckles, stress granules), displacing essential granule components (SFPQ, TDP-43, hnRNP A1) into a pathological aggregation-prone state.
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Curated pathway diagram from expert analysis
flowchart TD
A["RBM45 Disease Modification
Phosphorylation and Oxidation"]
B["Low Complexity Domain Shift
Aberrant Phase Separation"]
C["Stable RNA Condensates
Stress Granule Capture"]
D["TDP43 and HNRNPA1 Displacement
RNA Processing Hub Hijack"]
E["Splicing and Antioxidant Response Defects
Motor Neuron Stress"]
F["Insoluble RBM45 Aggregates
ALS FTD Pathology"]
G["RNA Homeostasis Collapse
Motor Neuron Degeneration"]
A --> B
B --> C
C --> D
D --> E
C --> F
E --> G
F --> G
style A fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7
style F fill:#b71c1c,stroke:#ef9a9a,color:#ef9a9a
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No price history recorded yet
No clinical trials data available
Freshness score = exp(-age×ln2/5): halves every 5 years. Green >0.6, Amber 0.3–0.6, Red <0.3.
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Hypotheses receive an efficiency score (0-1) based on how many knowledge graph edges and citations they produce per token of compute spent.
High-efficiency hypotheses (score >= 0.8) get a price premium in the market, pulling their price toward $0.580.
Low-efficiency hypotheses (score < 0.6) receive a discount, pulling their price toward $0.420.
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No DepMap CRISPR Chronos data found for RBM45,GSK3B,TDP-43,TARDBP,hnRNP A1,HNRNPA1,phase separation,Liquid droplet.
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