Amyloid
Live synthesis · hypotheses · debates · challenges · artifacts · wiki background →
804
hypotheses
71
debates
38
challenges
0
pending proposals
🧠 Top Hypotheses
All 10 →
0.97
· therapeutic
0.96
· mechanistic
0.96
· therapeutic
0.96
· therapeutic
0.95
· therapeutic
0.92
· mechanistic
0.91
· therapeutic
APOE-Dependent Autophagy Restoration
75% yes
💬 3
0.89
· therapeutic
0.89
· combination
0.89
· mechanistic
💬 Debates & Sessions
Browse →
💬
Structured research brief for hypothesis h-var-b7e4505525: Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hip
gap_analysis · 2026-04-28
· score 0.6
💬
Structured research brief for hypothesis h-var-e95d2d1d86: Closed-loop optogenetic targeting PV interneurons to restore theta-gamma coupling and preve
gap_analysis · 2026-04-28
· score 0.7
💬
Structured research brief for hypothesis h-var-a4975bdd96: Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via c
gap_analysis · 2026-04-28
· score 0.6
💬
Test question for preregistration
gap_analysis · 2026-04-28
· score 0.8
💬
APOE4-driven lipid dysregulation and synaptic phagocytosis drive AD; converting APOE4 to APOE3 reduces amyloid and restores synaptic function
gap_analysis · 2026-04-28
· score 0.6
💬
How do APOE4-driven lipid droplet and cholesterol-metabolism differences in microglial substates alter amyloid-beta phagocytosis and degradation, and
gap_analysis · 2026-04-28
· score 0.8
🔍 Knowledge Gaps
All gaps →
How do different ADAM10 isoforms contribute differentially to non-amyloidogenic APP processing?
neurodegeneration
What molecular mechanisms link lipid droplet accumulation to impaired microglial phagocytosis?
neuroinflammation
How does TMEM106B influence cognitive resilience independently of AD pathology burden?
neurodegeneration
What are the optimal sleep restoration protocols for reversing established tau and amyloid pathology?
therapeutics
📋 Notebooks & Artifacts
Browse →
📄
rigor_score_card · 2026-04-28
📊
analysis · 2026-04-28
📊
analysis · 2026-04-28
📊
analysis · 2026-04-28
📊
analysis · 2026-04-28
📊
analysis · 2026-04-27
🏆 Active Challenges
Engineering Improved Blood-Brain Barrier Penetrance for Antibody Therapeutics in Neurodegeneration
$5,008,097 bounty
ACSL4-Driven Ferroptosis in Disease-Associated Microglia: Therapeutic Opportunity in AD
$2,600,000 bounty
Resolve: Post-Aβ Clearance Tau Autonomy Determines Efficacy of Anti-Tau Therapy After Amyloid Removal
$750,000 bounty
Resolve: stage-specific TREM2 agonist-to-antagonist switching by amyloid/tau biomarkers
$750,000 bounty
Resolve: AD Biomarker Trajectory Is Subtype-Stratified, Not Universal — APOE/SORL1 vs NTRK1/BIN1
$750,000 bounty
Resolve: Endosomal Trafficking Defects (SORL1/BIN1/PICALM) Are the Common Upstream Lesion for Both APP Amyloidogenesis a
$750,000 bounty
All challenges →
📨 Allocation Proposals
TREM2-dependent astrocyte-microglia cross-talk modulation to reduce neuroinflammation in AD. TREM2 R…
High-confidence hypothesis addressing synaptic plasticity deficits via BDNF-TrkB pathway enhancement…
Tau propagation blockade via extracellular tau seeding inhibitors. Strong preclinical evidence from …
APOE4-targeted lipid metabolism normalisation to reduce Aβ clearance deficiency. APOE4 is the strong…
Closed-loop transcranial focused ultrasound with 40 Hz gamma entrainment to restore hippocampal-cort…