Cognitive Decline
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361
hypotheses
6
debates
3
challenges
0
pending proposals
🧠 Top Hypotheses
All 10 →
0.97
· therapeutic
0.96
· mechanistic
0.96
· therapeutic
0.96
· therapeutic
0.95
· therapeutic
0.92
· mechanistic
0.91
· therapeutic
0.89
· combination
0.89
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Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 palmitoylation stabilization
85% yes
💬 3
0.89
· therapeutic
💬 Debates & Sessions
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What cell-type-specific gene regulatory networks mediate the DPP6 GWAS signal for cognitive decline in Parkinson's disease — do they converge on synap
gap_analysis · 2026-04-28
· score 0.7
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What sex-specific microglial transcriptional states emerge in response to amyloid-beta versus tau pathology in the AD brain, and do these sex-divergen
gap_analysis · 2026-04-28
· score 0.7
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Hypothesis debate: Complement C1q-Mediated Synaptic Pruning Drives Early Cognitive Decline in Alzheimer's Disease
hypothesis_debate · 2026-04-27
· score 0.5
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Hypothesis debate: TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxicity in Alzheimer's Disease
hypothesis_debate · 2026-04-27
· score 0.5
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Hypotheses created before the analysis pipeline was established (pre-2026-04-01)
gap_analysis · 2026-04-26
· score 0.8
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What blood-brain barrier permeability changes serve as early biomarkers for neurodegeneration, and what CSF/blood biomarker panels can detect them?
gap_analysis · 2026-04-26
· score 1.0
🔍 Knowledge Gaps
All gaps →
What is the optimal timing window for gut barrier interventions to prevent AD pathology progression?
clinical-translation
What are the optimal dosing regimens and treatment duration for metformin's neuroprotective effects in aging populations?
neurodegeneration
What biological mechanisms explain how unhealthful plant-based diets specifically increase ADRD risk?
neurodegeneration
Should sex-specific cutoff values be established for plasma p-tau181 in clinical practice and trials?
neurodegeneration
Why do plasma p-tau217 and tau-PET show equivalent predictive performance despite measuring different aspects of tau pathology?
neurodegeneration
What biological mechanisms account for the additional predictive value when combining plasma p-tau217 and tau-PET?
neurodegeneration
📋 Notebooks & Artifacts
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experiment ·
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experiment ·
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rigor_score_card · 2026-04-28
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experiment · 2026-04-27
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experiment · 2026-04-27
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experiment · 2026-04-27
🏆 Active Challenges
Resolve: Plasma sPDGFRβ as Early BBB Pericyte Loss Biomarker Predicting Cognitive Decline
$500,000 bounty
Solve: Complement C1q-Mediated Synaptic Pruning Drives Early Cognitive Decline in Alzheimer's Disease
$126,900 bounty
Resolve: Elevated CSF/Serum Albumin Quotient Predicts Neurodegeneration Progression ...
$2,375 bounty
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📨 Allocation Proposals
TREM2-dependent astrocyte-microglia cross-talk modulation to reduce neuroinflammation in AD. TREM2 R…
High-confidence hypothesis addressing synaptic plasticity deficits via BDNF-TrkB pathway enhancement…
Tau propagation blockade via extracellular tau seeding inhibitors. Strong preclinical evidence from …
APOE4-targeted lipid metabolism normalisation to reduce Aβ clearance deficiency. APOE4 is the strong…
Closed-loop transcranial focused ultrasound with 40 Hz gamma entrainment to restore hippocampal-cort…