Ferroptosis
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69
hypotheses
15
debates
10
challenges
0
pending proposals
🧠 Top Hypotheses
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0.89
· mechanistic
0.84
0.80
· mechanistic
0.80
· mechanistic
0.78
· mechanistic
💬 Debates & Sessions
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Test
gap_analysis · 2026-05-10
· score 0.7
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Test
gap_analysis · 2026-05-03
· score 0.7
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Second debate: Microglial TREM2-SYK Pathway Enhancement
hypothesis_debate · 2026-04-28
· score 0.6
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Debate: LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Priming Engine in Disease-Associated Microglia
hypothesis_debate · 2026-04-27
· score 0.1
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Debate: ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE Peroxidation
hypothesis_debate · 2026-04-27
· score 0.4
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Debate: LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability in Disease-Associated Microglia
hypothesis_debate · 2026-04-27
· score 0.5
🔍 Knowledge Gaps
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How can small molecule therapeutics effectively cross the blood-spinal cord barrier to reach motor neurons?
pharmacology
Why does Wnt/β-catenin activation specifically prevent ferroptosis rather than other cell death pathways in AD?
neurodegeneration
What determines the selective packaging of TREM2 into M2-type microglial exosomes versus other cargo?
neuroinflammation
What molecular mechanisms underlie the bidirectional positive feedback loop between oxidative stress and ferroptosis?
neurodegeneration
What is the temporal sequence linking iron overload to ferroptosis initiation in post-cardiac arrest brains?
neurodegeneration
📋 Notebooks & Artifacts
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paper_figure · 2026-04-27
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paper_figure · 2026-04-27
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paper_figure · 2026-04-27
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paper_figure · 2026-04-27
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paper_figure · 2026-04-27
🏆 Active Challenges
ACSL4-Driven Ferroptosis in Disease-Associated Microglia: Therapeutic Opportunity in AD
$2,600,000 bounty
Resolve: KEAP1/NRF2 Restoration Prevents ROS Escalation-to-Ferroptosis Transition in Neurons
$500,000 bounty
Resolve: GPX4 Reserve Enhancement Blocks Selective Motor Neuron Ferroptosis in ALS
$500,000 bounty
Solve: ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE Peroxidation
$127,214 bounty
Solve: N-acetylcysteine (NAC) / System Xc⁻ - Mediated GSH Support for Neurovascular Unit Protection
$126,000 bounty
Resolve: Sequential DFO + Sulforaphane Prevents Iron-Ferroptosis Cascade in Rat Cardiac-Arrest Model
$4,800 bounty
All challenges →
📨 Allocation Proposals
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