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Figure 8: Summary of the mechanisms of ferroptosis in ALS and ferroptosis as a therapeutic...
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Created: 2026-04-27T05:03:56
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ID: paper-fig-dabb5fb4-3d6c-460d-af8c-b4e1f8
Figure 8Figure 8
Summary of the mechanisms of ferroptosis in ALS and ferroptosis as a therapeutic target for ALS. Riluzole, a glutamate antagonist, alleviates mitochondrial respiratory chain inhibition in ALS by preventing Ca² + overload and suppressing excitotoxic damage to motor neurons. Edaravone (EDA) inhibits ferroptosis under Cys deficiency and Xc − /GPX4 suppression. SPY1 reduces lipid peroxidation (LPO) and inhibits ferroptosis by upregulating the GCH1/BH4 axis and downregulating abnormally elevated TfR1 expression. Within endosomes, Fe³ + is reduced to Fe² + and transported into the cytosol via DMT1, increasing the risk of LIP formation and ferroptosis induction. Conversely, Fpn1 helps maintain intracellular Fe² + homeostasis by exporting excess Fe² + from the cell. ABAH, 4-aminobenzoic acid hydrazide; BH4, tetrahydrobiopterin; Ca² + , calcium ion; DMT1, divalent metal transporter 1; EDA, edaravone; ERK, extracellular signal-regulated kinase; Fer-1, ferrostatin-1; Fe² + /Fe³ + , ferrous/f
▸Metadata
| doi | 10.3389/fimmu.2025.1683876 |
| pmcid | PMC12714665 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC12714665/bin/fimmu-16-1683876-g008.jpg', 'type': 'external', 'tracked_at': '2026-04-27T12:03:56.650416'} |
| caption | Summary of the mechanisms of ferroptosis in ALS and ferroptosis as a therapeutic target for ALS. Riluzole, a glutamate antagonist, alleviates mitochondrial respiratory chain inhibition in ALS by preve |
| paper_id | dabb5fb4-3d6c-460d-af8c-b4e1f8896611 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC12714665/bin/fimmu-16-1683876-g008.jpg |
| image_path | |
| description | |
| figure_label | Figure 8 |
| figure_number | 8 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
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