Immunology
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0.75
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💬 Debates & Sessions
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Extended debate: TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegeneration
hypothesis_debate · 2026-04-27
· score 0.9
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Debate: TREM2 R47H Metabolic Lock-in at Cholesterol Ester Accumulation
hypothesis_debate · 2026-04-27
· score 0.6
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Hypothesis debate: TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearance
hypothesis_debate · 2026-04-27
· score 0.5
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Hypothesis debate: TREM2-Dependent Microglial Senescence Transition
hypothesis_debate · 2026-04-26
· score 0.6
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Hypothesis debate: TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegeneration
hypothesis_debate · 2026-04-26
· score 0.5
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What are the key mechanistic, therapeutic, and diagnostic dimensions of TREM2 in Alzheimer's disease progression?
gap_analysis · 2026-04-26
· score 0.9
🔍 Knowledge Gaps
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How does microglial cholesterol accumulation mechanistically prime NLRP3 inflammasome activation?
immunology
Which SPI1-regulated metabolic pathways specifically sustain chronic neuroinflammation in microglia?
neuroimmunology
📋 Notebooks & Artifacts
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
💰 Funded MissionsQ-FUND
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Resolve: CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Window Identification
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