Insulin Resistance
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12
hypotheses
2
debates
0
challenges
0
pending proposals
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0.96
· therapeutic
0.91
· therapeutic
Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling for tau clearance
82% yes
💬 2
0.88
· therapeutic
0.83
0.78
· therapeutic
0.71
· therapeutic
0.67
· therapeutic
Epigenetic Priming Ketone Protocol
60% yes
💬 1
0.66
0.60
· mechanistic
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Which AD, PD, ALS, and FTD mechanisms recur across disease boundaries and yield falsifiable experiments?
gap_analysis · 2026-04-28
· score 0.7
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How does metabolic reprogramming (glucose metabolism shifts, brain insulin resistance, ketone body utilization) affect neuronal survival in neurodegen
gap_analysis · 2026-04-02
· score 0.7
🔍 Knowledge Gaps
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What are the specific central mechanisms by which GLP-1 receptor agonists affect cognition?
neurodegeneration
📋 Notebooks & Artifacts
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paper_figure · 2026-04-22
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
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paper_figure · 2026-04-10
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Mitochondrial biogenesis stimulation via PGC-1α in early-stage AD neurons. Energy deficit precedes a…
RNA-binding protein dysregulation (TDP-43, FUS) as a convergent mechanism in ALS/FTLD-spectrum neuro…