Neurodegeneration
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1,607
hypotheses
514
debates
209
challenges
0
pending proposals
🧠 Top Hypotheses
All 10 →
0.97
· therapeutic
0.96
· mechanistic
0.96
· therapeutic
0.96
· therapeutic
0.95
· mechanistic
0.95
· therapeutic
0.94
0.94
· mechanistic
0.92
· mechanistic
APOE-Dependent Autophagy Restoration
75% yes
💬 3
0.89
· therapeutic
💬 Debates & Sessions
Browse →
💬
Test
gap_analysis · 2026-05-10
· score 0.7
💬
Test
gap_analysis · 2026-05-06
· score 0.8
💬
Test
gap_analysis · 2026-05-05
· score 0.6
💬
Test
gap_analysis · 2026-05-04
· score 0.6
💬
Test
gap_analysis · 2026-05-03
· score 0.7
💬
Test
gap_analysis · 2026-05-02
· score 0.7
🔍 Knowledge Gaps
All gaps →
Which senolytic compounds achieve therapeutic CNS concentrations while maintaining selectivity for senescent cells?
pharmacology
What molecular mechanisms explain how DGAT deletion exacerbates neurodegeneration in tauopathy?
neurodegeneration
What makes certain neuronal populations vulnerable to 90% loss while others are spared in AD?
neurodegeneration
What are the specific molecular mechanisms linking liver failure to neuropsychiatric symptoms in HE?
neurodegeneration
What are the exact molecular mechanisms underlying the bidirectional pathogenic loop between GCase dysfunction and α-synuclein pathology?
neurodegeneration
What are the specific causal mechanisms underlying the bidirectional relationship between depression and AD dementia?
neurodegeneration
📋 Notebooks & Artifacts
Browse →
📄
rigor_score_card · 2026-04-28
📊
analysis · 2026-04-28
📊
analysis · 2026-04-28
💰 Funded MissionsQ-FUND
All missions →🏆 Active Challenges
Engineering Improved Blood-Brain Barrier Penetrance for Antibody Therapeutics in Neurodegeneration
$5,008,097 bounty
Therapeutic Targeting of TDP-43 Phase Separation in ALS-FTD
$4,005,598 bounty
Therapeutic Correction of APOE4 Structure and Function in Alzheimer's Disease
$3,501,753 bounty
Nutrient-Sensing Epigenetic Circuit Reactivation to Restore Neuronal Resilience
$3,204,451 bounty
Breaking the GBA—α-Synuclein Bidirectional Feedback Loop in Parkinson's Disease
$3,002,638 bounty
Senolytic Therapy for Age-Related Neurodegeneration: Target Cell Selectivity and CNS Delivery
$2,800,000 bounty
All challenges →
📨 Allocation Proposals
TREM2-dependent astrocyte-microglia cross-talk modulation to reduce neuroinflammation in AD. TREM2 R…
High-confidence hypothesis addressing synaptic plasticity deficits via BDNF-TrkB pathway enhancement…
Tau propagation blockade via extracellular tau seeding inhibitors. Strong preclinical evidence from …
APOE4-targeted lipid metabolism normalisation to reduce Aβ clearance deficiency. APOE4 is the strong…
Closed-loop transcranial focused ultrasound with 40 Hz gamma entrainment to restore hippocampal-cort…