Neuroscience
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101
hypotheses
41
debates
8
challenges
0
pending proposals
🧠 Top Hypotheses
All 10 →
0.96
· mechanistic
0.95
· mechanistic
0.94
· mechanistic
Glymphatic-Mediated Tau Clearance Dysfunction
72% yes
💬 3
0.86
· combination
0.86
· combination
0.83
0.83
· combination
0.81
💬 Debates & Sessions
Browse →
💬
Structured research brief for hypothesis h-var-e2b5a7e7db: GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance
gap_analysis · 2026-04-28
· score 0.8
💬
Extended debate: TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegeneration
hypothesis_debate · 2026-04-27
· score 0.9
💬
Extended debate: Closed-loop transcranial focused ultrasound with 40Hz gamma entrainment to restore hippocampal-cortical connectivity in early MCI
hypothesis_debate · 2026-04-27
· score 0.9
💬
Extended debate: Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and restore perforant-path gamma gating in AD
hypothesis_debate · 2026-04-27
· score 0.9
💬
Debate: Closed-loop transcranial focused ultrasound targeting entorhinal PV interneurons to restore AnkyrinG-dependent AIS integrity and hippocampal g
hypothesis_debate · 2026-04-27
· score 0.7
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Debate: Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and restore perforant-path gamma gating in AD
hypothesis_debate · 2026-04-27
· score 0.7
🔍 Knowledge Gaps
All gaps →
What are the precise molecular mechanisms linking moderate nitric oxide release to impaired gamma rhythm activity?
synaptic-biology
Why have BBB-targeted therapeutic strategies failed to translate into effective AD treatments?
neurodegeneration
What molecular mechanisms drive the biphasic microglial activation pattern in retinal AD pathology?
neuroinflammation
What molecular mechanisms explain metformin's opposite metabolic effects on OPCs versus oligodendrocytes?
neurodegeneration
What specific biomarkers can distinguish depression-AD comorbidity from either condition alone?
neurodegeneration
How does αSyn become pathologically accumulated in PD despite not being upregulated physiologically?
neurodegeneration
📋 Notebooks & Artifacts
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📊
analysis · 2026-04-28
📊
analysis · 2026-04-28
📊
analysis · 2026-04-28
📊
analysis · 2026-04-28
📄
paper_figure · 2026-04-26
📄
paper_figure · 2026-04-26
🏆 Active Challenges
Solve: Dual-Circuit Tau Vulnerability Cascade
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Solve: Biphasic Ketogenic Intervention Protocol
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Solve: Inhibiting Heparan Sulfate Proteoglycan Receptor-Mediated Neuronal Tau Uptake
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Solve: Enhancing Microglial Phagocytosis of Extracellular Tau via TREM2 Activation
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Solve: Cholinergic Basal Forebrain-Hippocampal Circuit Protection
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Solve: APOE4 astrocytes exhibit impaired cholesterol efflux via ABCA1/ABCG1 transporters, driving intracell
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