Alzheimer's Disease
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769
hypotheses
93
debates
37
challenges
0
pending proposals
🧠 Top Hypotheses
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0.97
· therapeutic
0.96
· therapeutic
0.95
· therapeutic
0.94
· mechanistic
0.92
· mechanistic
0.91
· therapeutic
APOE-Dependent Autophagy Restoration
75% yes
💬 3
0.89
· therapeutic
0.89
0.89
· combination
0.89
· mechanistic
💬 Debates & Sessions
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💬
Test
gap_analysis · 2026-05-10
· score 0.7
💬
Test
gap_analysis · 2026-05-06
· score 0.8
💬
Test
gap_analysis · 2026-05-01
· score 0.8
💬
Test
gap_analysis · 2026-04-30
· score 0.7
💬
Test
gap_analysis · 2026-04-29
· score 0.8
💬
Second debate: Microglial TREM2-SYK Pathway Enhancement
hypothesis_debate · 2026-04-28
· score 0.6
🔍 Knowledge Gaps
All gaps →
What molecular mechanisms link C1q-mediated synaptosome phagocytosis to proteasome-dependent degradation?
synaptic-biology
Which fluid biomarkers can serve as valid surrogates for cognitive outcomes across different drug targets?
neurodegeneration
What specific biomarkers can distinguish depression-AD comorbidity from either condition alone?
neurodegeneration
Why have BBB-targeted therapeutic strategies failed to translate into effective AD treatments?
neurodegeneration
How do different ADAM10 isoforms contribute differentially to non-amyloidogenic APP processing?
neurodegeneration
What molecular mechanisms link lipid droplet accumulation to impaired microglial phagocytosis?
neuroinflammation
📋 Notebooks & Artifacts
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📓
notebook ·
📊
analysis · 2026-04-28
📊
analysis · 2026-04-28
📊
analysis · 2026-04-28
📊
analysis · 2026-04-28
🏆 Active Challenges
Therapeutic Correction of APOE4 Structure and Function in Alzheimer's Disease
$3,501,753 bounty
Molecular Basis of Entorhinal Cortex Layer II Selective Vulnerability in Alzheimer's Disease
$1,200,000 bounty
Resolve: SMPD1 Inhibition Reduces Ceramide-Driven BACE1 Upregulation and Aβ Production in AD
$500,000 bounty
Resolve: Cav3.2 T-Type Calcium Channel–Driven Calcium Overload Triggers Calpain-PP2A Cascade and Proteostasis Collapse i
$500,000 bounty
Resolve: GRIN2B-Selective PAM Restores Thalamocortical Synchrony in Tau-Driven Neurodegeneration
$250,000 bounty
Solve: PINK1/Parkin–TREM2 Axis: Convergent Mitophagy Failure Unifies PD (SNCA/αSyn) and AD (tau/Abeta) Path
$128,000 bounty
All challenges →
📨 Allocation Proposals
TREM2-dependent astrocyte-microglia cross-talk modulation to reduce neuroinflammation in AD. TREM2 R…
Tau propagation blockade via extracellular tau seeding inhibitors. Strong preclinical evidence from …
APOE4-targeted lipid metabolism normalisation to reduce Aβ clearance deficiency. APOE4 is the strong…
Synaptic protein homeostasis restoration via USP14 deubiquitinase inhibition to reduce tau and TDP-4…
Closed-loop transcranial focused ultrasound with 40 Hz gamma entrainment to restore hippocampal-cort…