protein

4EBP1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about 4EBP1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

Summary

The N-terminal region contains the minimal eIF4E-binding motif (YXXXXLΦ, where Φ represents a hydrophobic amino acid) that is essential for binding to eIF4E.

View on Wiki →

🔬 Protein Info

Gene Symbol	4EBP1PROTEIN
Function	is a critical regulator of cap-dependent translation initiation in eukaryotic cells.
Subcellular Localization	</strong></td><td>Cytoplasm, nucleus</td></tr>
Amino Acids	118 aa
Thr37 and Thr46	Primary mTOR phosphorylation sites; these priming phosphorylations create docking sites for subsequent phosphorylation
Ser65	Secondary site; phosphorylation here significantly reduces eIF4E binding affinity
Thr70	Tertiary site; phosphorylation further stabilizes the dissociated state
Ser83 and Ser101	Additional regulatory sites involved in cell cycle-dependent regulation 5
Associated Diseases	neurodegeneration
Interactions	MTOR
KG Connections	6 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

4E-BP1 Protein

protein · 1881 words

→

Pathway Diagram

graph TD
    4EBP1PROTEIN["4EBP1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    4EBP1PROTEIN -->|"implicated_in"| neurodegeneration
    style 4EBP1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found