MTOR

Understanding Entity Pages

This page aggregates everything SciDEX knows about MTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Mechanistic Target of Rapamycin - central kinase regulating autophagy, protein synthesis, and synaptic plasticity in neurodegeneration

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graph TD
    subgraph Signaling["Signaling"]
        MTOR["MTOR"] -->|"regulates"| Mtor["Mtor"]
        MTOR["MTOR"] -->|"regulates"| Autophagy["Autophagy"]
        MTOR["MTOR"] -.->|"inhibits"| Als["Als"]
        MTOR["MTOR"] -.->|"inhibits"| Autophagy_1["Autophagy"]
        MTOR["MTOR"] -.->|"inhibits"| Mtor_2["Mtor"]
        MTOR["MTOR"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
        AKT["AKT"] -->|"activates"| MTOR["MTOR"]
        PINK1["PINK1"] -->|"activates"| MTOR["MTOR"]
        LC3["LC3"] -->|"activates"| MTOR["MTOR"]
        ULK1["ULK1"] -->|"activates"| MTOR["MTOR"]
        SQSTM1["SQSTM1"] -->|"activates"| MTOR["MTOR"]
        PI3K["PI3K"] -.->|"inhibits"| MTOR["MTOR"]
    end
    subgraph Interactions["Interactions"]
        MTOR["MTOR"] -->|"interacts with"| Als_3["Als"]
    end
    subgraph Pathology["Pathology"]
        MTOR["MTOR"] -->|"associated with"| Als_4["Als"]
        MTOR["MTOR"] -->|"associated with"| Mtor_5["Mtor"]
    end
    style MTOR fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style Mtor fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Autophagy_1 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Mtor_2 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Als_3 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Als_4 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Mtor_5 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AKT fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style PINK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style LC3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ULK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style SQSTM1 fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style PI3K fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0