Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AD risk: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE4 | risk_factor_for | gene | 0.90 |
| TREM2 | risk_factor_for | gene | 0.90 |
| APOEε4 | risk_factor_for | gene | 0.90 |
| TREM2 | associated_with | gene | 0.90 |
| PLCG2 | associated_with | gene | 0.90 |
| microglial-expressed genes | risk_factor_for | gene | 0.90 |
| apoe4 | associated_with | disease | 0.90 |
| Sleep Disruption | increases_risk | phenotype | 0.70 |
| circadian rhythm | associated_with | phenotype | 0.70 |
| ALOX15 polymorphisms | risk_factor_for | gene | 0.70 |
| SIRPα polymorphisms | associated_with | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Female microglia exhibit heightened complement gene expressi | 0.610 | neurodegeneration | Synaptic pruning by microglia in neurode |
| Rare TREM2-TYROBP pathway variants complement standard PRS b | 0.380 | late-onset-alzheimers | Polygenic Risk Score Analysis for Late-O |
| Ethnic and Metabolic Epigenetic Clock Divergence Explains Di | 0.376 | - | Epigenetic clocks as biomarkers for Alzh |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.735
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.629
connectomics | 2026-04-16 | 13 hypotheses Top: 0.535
immunomics | 2026-04-16 | 13 hypotheses Top: 0.565
neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.586
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Epigenetic/circadian clocks and PCOS. [PMID:38600622] | Vatier C, Christin-Maitre S | Hum Reprod | 2024 | 0 |
| The role of cellular senescence in neurodegenerative diseases. [PMID:38744709] | Wang Y, Kuca K, You L, Nepovimova E, Heg | Archives of toxicology | 2024 | 0 |
| The role of cellular senescence in neurodegenerative diseases. [PMID:38744709] | Wang Y, Kuca K, You L, Nepovimova E, Heg | Archives of toxicology | 2024 | 0 |
| Exercise therapy to prevent and treat Alzheimer's disease. [PMID:37600508] | ["Pahlavani H"] | Frontiers in aging neuroscienc | 2023 | 0 |
| Exercise therapy to prevent and treat Alzheimer's disease. [PMID:37600508] | ["Pahlavani H"] | Frontiers in aging neuroscienc | 2023 | 0 |
| Interaction between Aβ and Tau in the Pathogenesis of Alzheimer's Disease. [PMID:34239348] | Zhang, Wei, Zhao, Ma, Jiang et al. | International journal of biolo | 2022 | 0 |
| Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive dec [PMID:35130907] | ["Liu Sen", "Fan Min", "Xu Jing-Xian", " | Journal of neuroinflammation | 2022 | 0 |
| Metabolic programs tailor T cell immunity in viral infection, cancer, and aging. [PMID:35235773] | Møller SH, Hsueh PC, Yu YR | Cell Metab | 2022 | 0 |
| Epigenetic clock: A promising biomarker and practical tool in aging. [PMID:36206857] | Duan R, Fu Q, Sun Y | Ageing Res Rev | 2022 | 0 |
| DNA methylation GrimAge version 2. [PMID:36516495] | Lu AT, Binder AM, Zhang J | Aging (Albany NY) | 2022 | 0 |
| Interaction between Aβ and Tau in the Pathogenesis of Alzheimer's Disease. [PMID:34239348] | Unknown | International journal of biolo | 2022 | 0 |
| Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive dec [PMID:35130907] | ["Liu Sen", "Fan Min", "Xu Jing-Xian", " | Journal of neuroinflammation | 2022 | 0 |
| A systematic review of biological, social and environmental factors associated w [PMID:33930583] | Oblak L, van der Zaag J, Higgins-Chen AT | Ageing Res Rev | 2021 | 0 |
| Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer [PMID:34116706] | Sun XY, Li LJ, Dong QX, Zhu J, Huang YR, | Journal of neuroinflammation | 2021 | 0 |
| Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer [PMID:34116706] | Sun XY, Li LJ, Dong QX, Zhu J, Huang YR, | Journal of neuroinflammation | 2021 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.57 · 2026-04-28
closed · Rounds: 4 · Score: 0.12 · 2026-04-27
closed · Rounds: 4 · Score: 0.42 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.47 · 2026-04-27
closed · Rounds: 4 · Score: 0.52 · 2026-04-27
closed · Rounds: 4 · Score: 0.72 · 2026-04-27
closed · Rounds: 4 · Score: 1.00 · 2026-04-26
closed · Rounds: 4 · Score: 0.82 · 2026-04-22
closed · Rounds: 4 · Score: 0.70 · 2026-04-21
Hypotheses and analyses mentioning AD risk in their description or question text
No additional research found