PLCG2

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLCG2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

A gene referenced in 1 knowledge graph relationship. Key connections: encodes PLCgamma2 (protein).

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graph TD
    PLCG2["<b>PLCG2</b>"]
    Cancer{"Cancer"}
    PLCG2 -->|"activates"| Cancer
    Carcinoma{"Carcinoma"}
    PLCG2 -->|"activates"| Carcinoma
    Ms{"Ms"}
    PLCG2 -->|"activates"| Ms
    PLCG2 -->|"inhibits"| Cancer
    PLCG2 -->|"inhibits"| Carcinoma
    Alzheimer{"Alzheimer"}
    PLCG2 -->|"associated with"| Alzheimer
    PLCG2 -->|"associated with"| Ms
    PLCG2 -->|"regulates"| Alzheimer
    Als{"Als"}
    PLCG2 -->|"associated with"| Als
    ABCB1["ABCB1"]
    PLCG2 -->|"contributes to"| ABCB1
    PARP1["PARP1"]
    PLCG2 -->|"contributes to"| PARP1
    DOT1L["DOT1L"]
    PLCG2 -->|"contributes to"| DOT1L
    DOT1L -->|"contributes to"| PLCG2
    ABCB1 -->|"contributes to"| PLCG2
    PARP1 -->|"contributes to"| PLCG2
    TREM2["TREM2"]
    TREM2 -->|"associated with"| PLCG2
    ABI3["ABI3"]
    ABI3 -->|"regulates"| PLCG2
    TREM2 -->|"regulates"| PLCG2
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| PLCG2
    AND["AND"]
    AND -->|"regulates"| PLCG2
    APP["APP"]
    APP -->|"associated with"| PLCG2
    ALZHEIMER_S_DISEASE -->|"associated with"| PLCG2
    NDUFAF7["NDUFAF7"]
    NDUFAF7 -->|"associated with"| PLCG2
    SHARPIN["SHARPIN"]
    SHARPIN -->|"associated with"| PLCG2
    style PLCG2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0