gene

adss2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about adss2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

0Analyses

1Outgoing

1Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ADSS2
Full Name	Adenylosuccinate Synthetase 2
Chromosome	1p31.3
Protein Type	Gene
Function	is a human gene encoding an enzyme essential for de novo purine nucleotide synthesis.
Subcellular Localization	and tissue distribution. While ADSS1 is primarily mitochondrial, ADSS2 shows both cytosolic and mitochondrial localizati
Molecular Weight	47 kDa
Amino Acids	432 aa
Exons	13
GeneCards	ADSS2
Human Protein Atlas	ADSS2
N-terminal domain	Contains the IMP-binding site
Central domain	Aspartate-binding region
C-terminal domain	GTP-binding site (substrate-level phosphorylation)
Energy status	ATP feedback inhibition
Associated Diseases	Neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ADSS2 — Adenylosuccinate Synthetase 2

gene · 1148 words

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Pathway Diagram

graph TD
    A["Regulatory elements"] --> B["adss2 gene"]
    B --> C["mRNA transcript"]
    C --> D["Protein product"]
    D --> E["Cellular function"]
    E --> F["Disease relevance"]
    B --> G["Variant effects"]
    G --> F
    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    class B gene
    class D protein

Outgoing (1)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ADSS2	data_in	dataset_row	0.00

Incoming (1)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ADSS2	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning adss2 in their description or question text

No additional research found