afg3l2

Understanding Entity Pages

This page aggregates everything SciDEX knows about afg3l2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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flowchart TD
    AFG3L2["AFG3L2"] -->|"causes"| Autosomal_Recessive_Ataxia["Autosomal Recessive Ataxia"]
    AFG3L2["AFG3L2"] -->|"associated with"| GDAP1["GDAP1"]
    AFG3L2["AFG3L2"] -->|"associated with"| MFSD8["MFSD8"]
    AFG3L2["AFG3L2"] -->|"associated with"| SETX["SETX"]
    AFG3L2["AFG3L2"] -->|"implicated in"| neurodegeneration["neurodegeneration"]
    Neurodegeneration["Neurodegeneration"] -->|"regulates"| Apoptosis["Apoptosis"]
    Neurodegeneration["Neurodegeneration"] -->|"activates"| Mtor["Mtor"]
    Neurodegeneration["Neurodegeneration"] -->|"activates"| Autophagy["Autophagy"]
    Neurodegeneration["Neurodegeneration"] -->|"therapeutic target"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    MFSD8["MFSD8"] -->|"causes"| Peripheral_Neuropathy["Peripheral Neuropathy"]
    MFSD8["MFSD8"] -->|"implicated in"| NEK1["NEK1"]
    MFSD8["MFSD8"] -->|"implicated in"| TBK1["TBK1"]
    MFSD8["MFSD8"] -->|"implicated in"| TBP["TBP"]
    Autosomal_Recessive_Ataxia["Autosomal Recessive Ataxia"] -->|"associated with"| Gait_Disturbance["Gait Disturbance"]
    Autosomal_Recessive_Ataxia["Autosomal Recessive Ataxia"] -->|"associated with"| Balance_Impairment["Balance Impairment"]
    style AFG3L2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Autosomal_Recessive_Ataxia fill:#ef5350,stroke:#333,color:#e0e0e0
    style GDAP1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style MFSD8 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style SETX fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style neurodegeneration fill:#006494,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
    style Apoptosis fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Mtor fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Autophagy fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Blood_Brain_Barrier fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Peripheral_Neuropathy fill:#ef5350,stroke:#333,color:#e0e0e0
    style NEK1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style TBK1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style TBP fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Gait_Disturbance fill:#5d2900,stroke:#333,color:#e0e0e0
    style Balance_Impairment fill:#5d2900,stroke:#333,color:#e0e0e0