GDAP1

Understanding Entity Pages

This page aggregates everything SciDEX knows about GDAP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

GDAP1 encodes a mitochondrial outer membrane protein critical for mitochondrial fission, peripheral nerve integrity, and neuronal survival. Mutations cause Charcot-Marie-Tooth disease.

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graph TD
    GDAP1["<b>GDAP1</b>"]
    Als{"Als"}
    GDAP1 -->|"regulates"| Als
    Neuropathy{"Neuropathy"}
    GDAP1 -->|"associated with"| Neuropathy
    Ms{"Ms"}
    GDAP1 -->|"contributes to"| Ms
    AUTOPHAGY["AUTOPHAGY"]
    GDAP1 -->|"contributes to"| AUTOPHAGY
    TFEB["TFEB"]
    GDAP1 -->|"activates"| TFEB
    LC3["LC3"]
    GDAP1 -->|"contributes to"| LC3
    Autophagy(["Autophagy"])
    GDAP1 -->|"contributes to"| Autophagy
    neurodegeneration["neurodegeneration"]
    GDAP1 -->|"implicated in"| neurodegeneration
    MOTOR_NEURONS["MOTOR NEURONS"]
    MOTOR_NEURONS -->|"contributes to"| GDAP1
    style GDAP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0