Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ALPHA_SYN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| C3 | activates | protein | 0.56 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Inhibition of autophagy in microglia and macrophages exacerbates innate immune r [PMID:36652438] | Hegdekar N, Sarkar C, Bustos S, Ritzel R | Autophagy | 2023 | 0 |
| Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's [PMID:37029500] | Yan YQ, Zheng R, Liu Y, Ruan Y, Lin ZH, | Aging cell | 2023 | 0 |
| Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like [PMID:36288697] | Li S, Fang Y, Zhang Y, Song M, Zhang X, | Cell reports | 2022 | 0 |
| Biomarker of Neuroinflammation in Parkinson's Disease. [PMID:35456966] | Liu TW, Chen CM, Chang KH | Int J Mol Sci | 2022 | 0 |
| NLRP3 inflammasome activation drives tau pathology. [PMID:31748742] | ["Ising C", "Venegas C", "Zhang S", "Sch | Nature | 2019 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ALPHA_SYN in their description or question text
Score: 0.662 · parkinson · 2026-04-27
N6-methyladenosine (m6A) hypermethylation of SNCA mRNA in substantia nigra dopaminergic neurons stabilises the transcrip
Score: 0.650 · neurodegeneration · 2026-04-24
Low-micromolar systemic SCFA exposure is unlikely to directly drive substantia nigra alpha-synuclein clearance, but colo
Score: 0.626 · neurodegeneration · 2026-04-28
m6A-dependent control of alpha-synuclein transcript fate and aggregation kinetics should produce a measurable proximal p
Score: 0.620 · neurodegeneration · 2026-04-15
## Mechanistic Overview H7: Enteric Nervous System Alpha-Synuclein Propagation Blocker via Gut Barrier Restoration start
Score: 0.612 · neurodegeneration · 2026-04-28
The question is likely underpowered or misleading unless analyses preserve the key strata: m6A, RNA, N6-, alpha-synuclei
Score: 0.608 · neurodegeneration · 2026-04-28
The debate supports treating this as a validation program before ranking it as a therapy. Perturbation should move a pro
Score: 0.606 · neurodegeneration · 2026-04-25
Specific lipoprotein particles bind fibril surfaces and preserve polymorph architecture and seeding fidelity outside the
Score: 0.582 · neurodegeneration · 2026-04-25
Membrane-derived cofactors in extracellular vesicles maintain polymorph fidelity and templating competence.
Score: 0.571 · neurodegeneration · 2026-04-04
## Mechanistic Overview Neuronal Subtype-Specific Alpha-Synuclein Expression Normalization starts from the claim that mo
Score: 0.560 · neurodegeneration · 2026-04-24
The classic butyrate neuroprotection narrative likely depends on pharmacologic exposure sufficient for HDAC inhibition,
Score: 0.550 · neurodegeneration · 2026-04-24
A key liability hypothesis is that low-range SCFA signaling can be receptor-biased toward inflammasome activation in sus
Score: 0.525 · parkinsons · 2026-04-26
We propose that GBA deficiency-driven accumulation of glucosylceramide (GlcCer) in lysosomal membranes creates ordered l
Score: 0.489 · neurodegeneration · 2026-04-25
Electrostatic bridging by glycans and low-abundance proteins preserves disease-relevant fibril architecture.