Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about aph1a: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | APH1A |
| Aliases | Page for APH1A Gene, Page for APH1A Protein |
| Chromosome | 1p36.22 |
| Protein Family | Aph-1 family (gamma-secretase) |
| Function | ### Gamma-Secretase Complex Component |
| Primary Expression | Brain (cerebral cortex, hippocampus, cerebellum), Heart, Liver, Kidney, Pancreas |
| Subcellular Localization | Endoplasmic reticulum, Golgi, plasma membrane |
| Molecular Weight | 28.5 kDa |
| Amino Acids | 257 aa |
| Pathways | notch, Notch signaling |
| UniProt ID | Q9Y6X0 |
| Ensembl ID | ENSG00000144024 |
| GeneCards | APH1A |
| Human Protein Atlas | APH1A |
| Associated Diseases | Alzheimer's Disease, Familial Alzheimer's Disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
APH1A["APH1A"] -.->|"inhibits"| APH1B["APH1B"]
APH1A["APH1A"] -.->|"inhibits"| PSEN1["PSEN1"]
APH1A["APH1A"] -.->|"inhibits"| PSEN2["PSEN2"]
APH1A["APH1A"] -->|"implicated in"| neurodegeneration["neurodegeneration"]
style APH1A fill:#4a1a6b,stroke:#333,color:#e0e0e0
style APH1B fill:#4a1a6b,stroke:#333,color:#e0e0e0
style PSEN1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style PSEN2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style neurodegeneration fill:#006494,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| APH1B | inhibits | gene | 0.60 |
| PSEN1 | inhibits | gene | 0.60 |
| PSEN2 | inhibits | gene | 0.60 |
| benchmark_ot_ad_answer_key:APH1A | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| benchmark_ot_ad_answer_key:APH1A | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||