gene

APH1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about APH1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

101Connections

0Hypotheses

0Analyses

50Outgoing

34Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	APH1B
Full Name	Aph-1 Homolog B, Gamma-Secretase Subunit
Aliases	APH-1B
Chromosome	15q22.2
Function	Gamma-secretase complex subunit, cleaves APP and Notch
Subcellular Localization	Substrate Processing: Contributes to the recognition and processing of various type I transmembrane protein substrat
Molecular Weight	28.5 kDa
Amino Acids	257
Pathways	Gamma-secretase complex, Notch signaling, APP processing
UniProt ID	Q8WW43
NCBI Gene ID	83464
Ensembl ID	ENSG00000138613
OMIM	607630
GeneCards	APH1B
Human Protein Atlas	APH1B
Associated Diseases	AD, AMI, Als, Alzheimer, Alzheimer's disease, RA
Interactions	APOE, IL6, SREBF1, PSEN2, A2M, DHCR24
KG Connections	101 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: APH1B — AlphaFold Q8WW43 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    APH1B["APH1B"] -->|"interacts"| Alzheimer["Alzheimer"]
    style Alzheimer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    APH1B["APH1B"] -->|"interacts"| Tumor["Tumor"]
    style Tumor fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    APH1B["APH1B"] -->|"interacts"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    APH1B["APH1B"] -->|"interacts"| APOE["APOE"]
    style APOE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    APH1B["APH1B"] -->|"interacts"| IL6["IL6"]
    style IL6 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    APH1B["APH1B"] -->|"interacts"| SREBF1["SREBF1"]
    style SREBF1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    APH1B["APH1B"] -->|"interacts"| PSEN2["PSEN2"]
    style PSEN2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    NCSTN["NCSTN"] -->|"interacts"| APH1B["APH1B"]
    style NCSTN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    FAS["FAS"] -->|"interacts"| APH1B["APH1B"]
    style FAS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    TNF["TNF"] -->|"interacts"| APH1B["APH1B"]
    style TNF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    LMNA["LMNA"] -->|"interacts"| APH1B["APH1B"]
    style LMNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    DHCR24["DHCR24"] -->|"interacts"| APH1B["APH1B"]
    style DHCR24 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style APH1B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (67)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
Alzheimer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
APOE	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
PSEN2	interacts_with	gene	0.60
A2M	interacts_with	gene	0.60
DHCR24	interacts_with	gene	0.60
HMGCR	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
PEN2	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
DAPK1	interacts_with	gene	0.60
HSPG2	interacts_with	gene	0.60
IL1B	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
EIF2AK2	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
FAS	interacts_with	gene	0.60
DYNEIN	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
NCSTN	interacts_with	gene	0.60
Dynein	interacts_with	protein	0.60
Kinesin	interacts_with	protein	0.60
APP	regulates	gene	0.60
BACE1	regulates	gene	0.60
BACE2	regulates	gene	0.60
NCSTN	regulates	gene	0.60
PEN2	regulates	gene	0.60
PSEN1	regulates	gene	0.60
PSEN2	regulates	gene	0.60
PSEN1	inhibits	gene	0.60
PSEN2	inhibits	gene	0.60
PSEN1	associated_with	gene	0.60
PSEN2	associated_with	gene	0.60
APOE	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
SPI1	associated_with	gene	0.60
Cholesterol	interacts_with	pathway	0.60
Apoptosis	interacts_with	pathway	0.60
Amyloid	interacts_with	pathway	0.60
ALZHEIMER	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
AND	interacts_with	gene	0.60

Incoming (34)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
NCSTN	interacts_with	gene	0.60
FAS	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
DHCR24	interacts_with	gene	0.60
EIF2AK2	interacts_with	gene	0.60
IL1B	interacts_with	gene	0.60
DAPK1	interacts_with	gene	0.60
HMGCR	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
HSPG2	interacts_with	gene	0.60
PSEN2	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
A2M	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
PEN2	interacts_with	gene	0.60
DYNEIN	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
ADAM10	regulates	gene	0.60
APH1A	inhibits	gene	0.60
ADAM10	associated_with	gene	0.60
MITOCHONDRIAL DNA	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
AMYLOID	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
TFCP2	interacts_with	gene	0.60
benchmark_ot_ad_answer_key:APH1B	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

APH1B

Understanding Entity Pages

Wiki Pages (21)

APH1B Gene - Anterior Pharynx Defective 1 Homolog B

PMN310 Anti-Amyloid for AD (NCT06750432)

PEN2 Gene

Gamma-Secretase Complex (γ-Secretase)

Apoptosis Pathway in Neurodegeneration

NICASTRIN Gene

Presenilin-1

A2M Gene

PSEN1 Protein (Presenilin-1)

PEN2 Protein

PSEN2 Protein (Presenilin-2)

APH1A Gene - Anterior Pharynx Defective 1 Homolog A

APH1A Protein - Gamma-Secretase Subunit

EIF2AK2 — Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2

PSENEN Gene - Presenilin Enhancer

PEN-2 Protein - Gamma-Secretase Subunit

APH1A Gene

Anterior Pharynx Defective 1 (APH-1) Protein

Presenilin Enhancer 2 (PEN-2) Protein