Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about arhgef6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ARHGEF6 |
| Full Name | Rho Guanine Nucleotide Exchange Factor 6 |
| Aliases | Rho Guanine Nucleotide Exchange Factor 6 / alpha-PIX |
| Chromosome | Xq26.3 |
| Function | is a Rho family guanine nucleotide exchange factor (GEF) that activates Rho GTPases including Rac1, Cdc42, and RhoA. |
| Primary Expression | Brain (hippocampus, cortex, cerebellum), testis, lung |
| Molecular Weight | 87 kDa |
| Amino Acids | 759 aa |
| UniProt ID | [Q9Y5M8](https://www.uniprot.org/uniprotkb/Q9Y5M8/entry) |
| Ensembl ID | ENSG00000129654 |
| GeneCards | ARHGEF6 |
| Human Protein Atlas | ARHGEF6 |
| Substrate Specificity | Prefers Rac1 over RhoA; shows moderate activity toward Cdc42 |
| Catalytic Mechanism | Promotes GDP release and GTP binding to activate Rac1/Cdc42 |
| Regulation | Activity modulated by binding to PAK (p21-activated kinase), PIXIP, and post-translational modifications |
| Associated Diseases | Neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["Regulatory elements"] --> B["arhgef6 gene"]
B --> C["mRNA transcript"]
C --> D["Protein product"]
D --> E["Cellular function"]
E --> F["Disease relevance"]
B --> G["Variant effects"]
G --> F
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
class B gene
class D protein| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ARHGEF6 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ARHGEF6 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning arhgef6 in their description or question text
No additional research found