Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about arid2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet.
No AI portrait yet
| Gene Symbol | ARID2 |
| Full Name | AT-Rich Interaction Domain 2 |
| Chromosome | 12q12 |
| Function | is a defining subunit that distinguishes PBAF from canonical BAF (cBAF) and non-canonical BAF (ncBAF) complexes. |
| UniProt ID | [Q68CP9](https://www.uniprot.org/uniprot/Q68CP9) |
| Ensembl ID | ENSG00000189079 |
| GeneCards | ARID2 |
| Human Protein Atlas | ARID2 |
| Chromatin targeting | The ARID domain of ARID2 recognizes AT-rich DNA sequences prevalent in gene regulatory regions, directing PBAF to specific genomic loci including neural gene enhancers and promoters |
| Complex assembly | ARID2 serves as a scaffolding subunit that stabilizes PBAF-specific components including PBRM1 (polybromo-1/BAF180), BRD7, and PHF10/BAF45a |
| Enhancer regulation | PBAF is preferentially recruited to super-enhancers and poised enhancers marked by H3K4me1, where it facilitates enhancer activation during neural differentiation |
| Interferon signaling | ARID2 is required for interferon-stimulated gene (ISG) expression, linking chromatin remodeling to innate immune responses in microglia and astrocytes |
| DNA damage response | PBAF is rapidly recruited to DNA double-strand breaks, where it promotes non-homologous end joining (NHEJ) repair by facilitating access of repair machinery to damaged chromatin |
| Cerebellum | Purkinje cells show robust ARID2 expression, reflecting requirements for cerebellar chromatin regulation |
| Developing brain | Peak expression during embryonic neurogenesis (E12-E18 in mouse), with maintained but reduced adult levels |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["Regulatory elements"] --> B["arid2 gene"]
B --> C["mRNA transcript"]
C --> D["Protein product"]
D --> E["Cellular function"]
E --> F["Disease relevance"]
B --> G["Variant effects"]
G --> F
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
class B gene
class D protein| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ARID2 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ARID2 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning arid2 in their description or question text
No additional research found