| Gene Symbol | ARID2 |
| Full Name | AT-Rich Interaction Domain 2 |
| Chromosome | 12q12 |
| Function | is a defining subunit that distinguishes PBAF from canonical BAF (cBAF) and non-canonical BAF (ncBAF) complexes. |
| UniProt ID | [Q68CP9](https://www.uniprot.org/uniprot/Q68CP9) |
| Ensembl ID | ENSG00000189079 |
| GeneCards | ARID2 |
| Human Protein Atlas | ARID2 |
| Chromatin targeting | The ARID domain of ARID2 recognizes AT-rich DNA sequences prevalent in gene regulatory regions, directing PBAF to specific genomic loci including neural gene enhancers and promoters |
| Complex assembly | ARID2 serves as a scaffolding subunit that stabilizes PBAF-specific components including PBRM1 (polybromo-1/BAF180), BRD7, and PHF10/BAF45a |
| Enhancer regulation | PBAF is preferentially recruited to super-enhancers and poised enhancers marked by H3K4me1, where it facilitates enhancer activation during neural differentiation |
| Interferon signaling | ARID2 is required for interferon-stimulated gene (ISG) expression, linking chromatin remodeling to innate immune responses in microglia and astrocytes |
| DNA damage response | PBAF is rapidly recruited to DNA double-strand breaks, where it promotes non-homologous end joining (NHEJ) repair by facilitating access of repair machinery to damaged chromatin |
| Cerebellum | Purkinje cells show robust ARID2 expression, reflecting requirements for cerebellar chromatin regulation |
| Developing brain | Peak expression during embryonic neurogenesis (E12-E18 in mouse), with maintained but reduced adult levels |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |